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Progress in Neurobiology, 1996
Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Cannabinoids are the constituents of the marijuana plant (cannabis sativa) of which the major active ingredient is delta-9-tetrahydrocannabinol (delta 9-THC). Rapid progress has been achieved in marijuana research in the last five years than in the thousands of years that marijuana has been used in human history. For many decades therefore, research on
E S, Onaivi +2 more
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Cannabinoid Receptors and Their Role in Neuroprotection
NeuroMolecular Medicine, 2005Two G protein-coupled receptors for marijuana's psychoactive component, Delta9-tetrahydrocannabinol, have been cloned to date, the cannabinoid CB1 and CB2 receptors. These two proteins, the endogenous lipids that activate them, also known as endocannabinoids, and the proteins for the biosynthesis and inactivation of these ligands constitute the ...
M van der Stelt, V Di Marzo
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Pharmacology of Cannabinoid Receptors
Annual Review of Pharmacology and Toxicology, 1995Two subtypes of cannabinoid receptors, CB1 and CB2, have been described to date, although future investigations may elucidate other receptors. The actions of cannabimimetic agents via CB1 receptors in brain are mediated by GI/O to inhibit adenylate cyclase and Ca2+ channels. Little is known about signal transduction mechanisms utilized by CB2 receptors.
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The evolution of cannabinoid receptors in cancer
WIREs Mechanisms of Disease, 2023AbstractCannabis sativa (cannabis) has been used as a therapeutic treatment for centuries treating various diseases and disorders. However, racial propaganda led to the criminalization of cannabis in the 1930s preventing opportunities to explore marijuana in therapeutic development.
Nakea M. Pennant, Cimona V. Hinton
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Cannabinoid receptors and pain
Progress in Neurobiology, 2001Mammalian tissues contain at least two types of cannabinoid receptor, CB(1) and CB(2), both coupled to G proteins. CB(1) receptors are expressed mainly by neurones of the central and peripheral nervous system whereas CB(2) receptors occur centrally and peripherally in certain non-neuronal tissues, particularly in immune cells.
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Canonical Cannabinoid Receptors
This chapter will review the basic pharmacology of the canonical cannabinoid receptors. The endocannabinoid system is a complex signalling network involved in a wide range of physiological processes, including pain modulation, appetite regulation, and synaptic plasticity.Beth, Ehrlich +3 more
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Cannabinoid Receptor Signaling
2005The cannabinoid receptor family currently includes two types: CB1, characterized in neuronal cells and brain, and CB2, characterized in immune cells and tissues. CB1 and CB2 receptors are members of the superfamily of seven-transmembrane-spanning (7-TM) receptors, having a protein structure defined by an array of seven membrane-spanning helices with ...
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Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
Biochemical Pharmacology, 2019Cannabinoid receptors type 1 (CB1) and type 2 (CB2) are promising targets for a number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among others. Upon ligand-mediated activation of these receptors, multiple receptor conformations could be stabilized, resulting in a complex pattern of possible intracellular effects. Although
Elise Wouters +3 more
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Evidence for a Cannabinoid Receptor in Immunomodulation by Cannabinoid Compounds
1993A number of structurally related cannabinoid compounds, including the major psychoactive component of marihuana, delta-9-tetrahydrocannabinol (Δ9-THC), have been widely established as being immunosuppressive. Although much has been learned with respect to which immune responses demonstrate sensitivity to modulation by cannabinoids, the mechanism(s ...
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Cannabinoid Receptors as Therapeutic Targets
Current Pharmaceutical Design, 2006The cannabinoid receptors CB1 and CB2 are family A, G-protein Coupled Receptors that mediate the effects of cannabinoids, a class of compounds that are so named because the first members were isolates of the cannabis plant. In recent history, there has been much anecdotal evidence that the potent and diverse physiological responses produced by these ...
Spiro, Pavlopoulos +3 more
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