Results 131 to 140 of about 25,784 (209)

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis. [PDF]

MedComm (2020)
Chen J, Guan X, Wu W, Wu L, Liu Y, Zeng D, Dang J, Zhao J, Wang J, Yuan J, Fan X, Pan Y, Olsen N, Zheng SG.   +13 more
europepmc   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer‐Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice

MedComm, Volume 7, Issue 2, February 2026.
We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang, Longhai Yuan, Yun Xie, Yun Yang, Yanan Zhou, Junbing Wang, Hao Yang, Rui Peng, Jiali Xu, Wenhai Yu, Qing Huang, Wenqi Quan, Baisheng Li, Youchun Wang, Shuaiyao Lu   +14 more
wiley   +1 more source

Combining AlphaFold with Focused Virtual Library Design in the Development of Novel CCR2 and CCR5 Antagonists. [PDF]

J Chem Inf Model
Essa K, Noorman van der Dussen K, Yao Y, Bleijs B, Ortiz Zacarias NV, Heitman LH, van Westen GJP, Jespers W, van der Es D, Šícho M.   +9 more
europepmc   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

Dual Roles of CD147 in Regulating THP-1 Monocyte Migration and MCP-1-Induced Inflammatory Responses. [PDF]

Int J Mol Sci
Intasai N, Sornsuwan K, Juntit OA, Pamonsupornwichit T, Thongheang K, Jantaree P, Tayapiwatana C.   +6 more
europepmc   +1 more source

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole Guerrera, Alexandria Regan, Liqin Lin, Erica Schwarz, Aurelien Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam B. Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, Min‐Jong Kang, Danielle R. Bruns, Patty J. Lee, George Tellides, Jay D. Humphrey, Naftali Kaminski, Abhay B. Ramachandra, Edward P. Manning   +22 more
wiley   +1 more source

Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity. [PDF]

Front Med (Lausanne)
Macaubas C, Bayram B, Hussein N, Jager A, Davis KL, Graf J, Nakamura M, Zisman D, Mellins ED.   +8 more
europepmc   +1 more source

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans

Immunology &Cell Biology, Volume 104, Issue 2, Page 109-124, February 2026.
In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne, Naeimeh Tavakolinia, Louis Perriman, Wiebke Moskorz, Christine Cosmovici, Andreas Walker, Lara Olejnik, Katharina Raba, Mei RM Du, Fernando J Rossello, Igor E Konstantinov, Stuart P Berzins, Daniel G Pellicci, Jörg Timm   +13 more
wiley   +1 more source

Differential peritoneal resident macrophage depletion and omental milky spot disruption after high versus low clodronate‐loaded liposome dose treatment

Immunology &Cell Biology, Volume 104, Issue 2, Page 139-149, February 2026.
In this study, we found that intraperitoneal injection of a high (standard) clodronate‐loaded liposome dose induced persistent peritoneal macrophage depletion, paralleled by marked inflammation and compromised omental integrity. Conversely, low liposome dose caused transient macrophage depletion, low inflammation and no omental alterations, ensuring ...
Margarita Ferriz, Natalia Álvarez‐Ladrón, Alejandra Gutiérrez‐González, Marta H. Fernández‐Sesma, Ana Starešinčić, Carlos Ardavín   +5 more
wiley   +1 more source

CCR2/CXCR6 enhances tumor infiltration and antitumor efficacy of MSLN CAR-T cells. [PDF]

Cell Mol Life Sci
Zhang Y, Zhao L, Liu J, Yang X, Chen T, Chen Z, Li W, Hu Z, Pan F, Chen J, He L, Guo Z.   +11 more
europepmc   +1 more source