Results 171 to 180 of about 43,606 (294)

Cytokines and chemokines in Mycobacterium tuberculosis infection [PDF]

, 2016
Cooper, Andrea, Domingo-Gonzalez, Racquel, Khader, Shabaana A, Prince, Oliver   +3 more
core   +2 more sources

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Inflammatory Mediators of Alzheimer's Disease Characterized in a Mouse Model (APP/PS1). [PDF]

NeuroSci
Jorda A, Alvarez-Gamez K, Campo-Palacio I, Campos-Campos J, Colmena C, Singh SK, Miralles MJC, Aldasoro C, Aldasoro M, Valles SL.   +9 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

The role of chemokines and their receptors in cardiovascular diseases. [PDF]

Front Immunol
Srikanth S, DeVito L, Constantinesco NJ, Gopal R.   +3 more
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, Volume 13, Issue 18, 27 March 2026.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell-Derived Extracellular Vesicles in Rheumatoid Arthritis. [PDF]

MedComm (2020)
Chen J, Guan X, Wu W, Wu L, Liu Y, Zeng D, Dang J, Zhao J, Wang J, Yuan J, Fan X, Pan Y, Olsen N, Zheng SG.   +13 more
europepmc   +1 more source

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β [PDF]

, 2018
et al,, Gelman, Andrew E, Hsiao, Hsi-Min, Kreisel, Daniel, Lavine, Kory J, Li, Wenjun, Liu, Yongjian, Luehmann, Hannah P, Puri, Varun, Ruiz-Perez, Daniel, Scozzi, Davide, Spahn, Jessica H, Takahashi, Tsuyoshi, Tanaka, Satona, Turam, Cem   +14 more
core   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh, Annika Salvers, Judith Piesker, Shenja Buchholz, Rabea Lange, Sabine Ameling, Leif Steil, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Frank U. Weiss, Matthias Sendler, Juliane Glaubitz   +13 more
wiley   +1 more source