Results 151 to 160 of about 7,919 (172)

LATE-BREAKING ABSTRACT: A novel role for CCR3 in promoting airways hyperreactivity; Role for CCR3-muscarinic M3 receptor heterodimers

5.1 Airway Pharmacology and Treatment, 2015
We have developed a novel therapeutic inhibitor against the chemokine receptor CCR3 for allergic asthma that significantly inhibited the MCh PC 20 response in a Phase IIa trial in mild-to-moderate asthmatics. In vivo , AXP1275 had shown significant efficacy in reducing inflammatory mediators and cellular infiltrates in non-human primate models of ...
Kevin Bacon, Emma Moss, Karen Bingham, Louis-Philippe Boulet, Mark Fitzgerald, Gail Gauvreau, Paul O'Byrne, Taylor Gilliland, Tracy Handel, Tai-Wei Ly, Stefen Boehme   +10 more
openaire   +1 more source

CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 in inflammation

2023
The CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 (iCCRs) play a critical role in orchestrating the recruitment of leukocytes to inflamed areas. However, excessive leukocyte accumulation during inflammation can cause tissue damage and various inflammatory disorders, making iCCRs a promising target for therapeutic interventions.
openaire   +2 more sources

N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists

Bioorganic and Medicinal Chemistry Letters, 2005
The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
John Roderick, Joseph B Santella, Carl P Decicco   +2 more
exaly   +3 more sources

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

Science, 1997
There is growing evidence that T helper cell subsets (T H 1 and T H 2) can be differentially recruited to promote different types of inflammatory reactions. Murine T H 1 but not T H 2 cells are recruited through P- and E-selectin into inflamed ...
F, Sallusto, C R, Mackay, A, Lanzavecchia   +2 more
openaire   +2 more sources

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Bioorganic & Medicinal Chemistry Letters, 2001
Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.
D, Dhanak, L T, Christmann, M G, Darcy, R M, Keenan, S D, Knight, J, Lee, L H, Ridgers, H M, Sarau, D H, Shah, J R, White, L, Zhang   +10 more
openaire   +2 more sources

Activation of epidermal growth factor receptor via CCR3 in bronchial epithelial cells

Biochemical and Biophysical Research Communications, 2004
We have previously found that bronchial epithelial cells express CCR3 whose signaling elicits mitogen-activated protein (MAP) kinase activation and cytokine production. Several investigators have focused on the signaling crosstalk between G protein-coupled receptors (GPCRs) and epidermal growth factor receptor (EGFR) in cancer cells.
Tetsuya, Adachi, Chang-Hao, Cui, Akira, Kanda, Hiroyuki, Kayaba, Ken, Ohta, Junichi, Chihara   +5 more
openaire   +2 more sources

Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets

Blood, 2000
Platelets are known to contain platelet factor 4 and β-thromboglobulin, α-chemokines containing the CXC motif, but recent studies extended the range to the β-family characterized by the CC motif, including RANTES and Gro-α. There is also evidence for expression of chemokine receptors CCR4 and CXCR4 in platelets.
Clemetson, Kenneth John, Clemetson, JM, Proudfoot, AE, Power, CA, Baggiolini, M, Wells, TN   +5 more
openaire   +5 more sources

Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: Implications for myelination

Journal of Neuroimmunology, 2006
Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes.
Maysami, Samaneh, Nguyen, Dan, Zobel, Franziska, Heine, Sandra, Höpfner, Michael, Stangel, Martin   +5 more
openaire   +3 more sources

Circulating chemokine eotaxin and chemokine receptor CCR3 in allergic patients.

The Egyptian journal of immunology, 2010
Eotaxin is a chemokine with a selective eosinophil chemoattraction and its receptor is the chemokine receptor CCR3. The presence of CCR3 on Th2 lymphocytes is of particular interest. This work was performed to evaluate circulating level of chemokine eotaxin and CCR3 expression in allergic patients.
Ensaf A A, Azazi, Suzan M, Bakir, Heba A, Mohtady, Amal A, Almonem   +3 more
openaire   +1 more source

Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.

Biology of reproduction, 2000
Eosinophils are present in human endometrium only immediately before and during menstruation, suggesting a role in that process. The expression of the eosinophil chemoattractant, eotaxin, and its receptor, CCR3, within the human endometrium were investigated by immunohistochemical analysis of tissue sections spanning the entire menstrual cycle. Eotaxin
J, Zhang, L J, Lathbury, L A, Salamonsen
openaire   +1 more source