Results 121 to 130 of about 33,714 (244)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates [PDF]

, 1996
We examined the ability of chemokine receptors and related G protein–coupled receptors to facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with CD4, the HIV-1 receptor, allowed cell lines resistant to most primary HIV ...
Sun, Ying, Newman, Walter, Mackay, Charles R, Choe, Hyeryun, Hyeryun Choe, Gerard, Craig, Nancy Sullivan, Ying Sun, Lijun Wu, Sullivan, Nancy, Michael Farzan, Paul D Ponath, Charles R Mackay, Gerard, Norma, Craig Gerard, Sodroski, Joseph, Wu, Lijun, Barrett Rollins, LaRosa, Gregory, Joseph Sodroski, Rollins, Barrett, Farzan, Michael, Ponath, Paul D, Gregory LaRosa, Walter Newman, Norma Gerard   +25 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Полиморфизм гена хемокинового рецептора CCR5 у больных рассеянным склерозом в Сибирском регионе [PDF]

, 2006
Multiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result
P. A. Gervas, Ю. Ю. Орлова, П. А. Гервас, N. V. Cherdyntseva, V. M. Alifirova, В. М. Алифирова, Н. В. Чердынцева, Yu. Yu. Orlova   +7 more
core   +2 more sources

CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy

Molecules, 2019
HIV entry in the host cell requires the interaction with the CD4 membrane receptor, and depends on the activation of one or both co-receptors CCR5 and CXCR4.
Fedora Grande, Maria Antonietta Occhiuzzi, Bruno Rizzuti, Giuseppina Ioele, Michele De Luca, Paola Tucci, Valentina Svicher, Stefano Aquaro, Antonio Garofalo   +8 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Role of the β-Chemokine Receptors CCR3 and CCR5 in Human Immunodeficiency Virus Type 1 Infection of Monocytes and Microglia [PDF]

, 1998
Human immunodeficiency virus type 1 (HIV-1) infection in mononuclear phagocyte lineage cells (monocytes, macrophages, and microglia) is a critical component in the pathogenesis of viral infection. Viral replication in macrophages serves as a reservoir, a
Mackay, Charles R., Jenae Limoges, Charles R. Mackay, Qi Xia, Meng, Gendelman, Howard, Yuri Persidsky, Howard E. Gendelman, Meng Qi Xia, Persidsky, Yuri, Limoges, Janae, Bradley T. Hyman, Nukuna, Adeline, Anuja Ghorpade, Paul Bock, Bock, Paul, Che, Myhanh, Myhanh Che, Adeline Nukuna, Ghorpade, Anuja, Hyman, Bradley T.   +19 more
core   +2 more sources

Neutrophil‐Macrophage Interactions Shape Inflammatory Macrophage Remodeling in Gastric Cancer During Chemo‐Immunotherapy

Cancer Science, EarlyView.
PD‐1 blockade combined with chemotherapy induces MHC‐II+ inflammatory neutrophils in gastric cancer, which engage in dynamic crosstalk with macrophages to remodel the tumor microenvironment toward a pro‐inflammatory state, thereby amplifying antitumor immune responses.
Keita H. Nagaoka, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Takuya Nakatsuru, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Sai M. Pulukuri, Yuko Ishii, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance

Cell Proliferation, EarlyView.
SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu, Xiya Qiu, Wenying Qu, Yue Ma, Mingyuan Bao, Yuxuan Feng, Xiaochu Wang, Tao Zhou, Bo Zheng, Shunyu Hou, Yu Xia, Qingxia Meng   +11 more
wiley   +1 more source