Results 141 to 150 of about 33,714 (244)

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Effects of CCL2 chemokine missense mutations on CCR5 receptor affinity: a computational study in the context of HIV infection regulator discovery

Инфекция и иммунитет
Introduction. HIV entry into host cells requires CD4 receptors and CCR5 co-receptors. Natural CCR5 ligands can inhibit HIV through steric blocking and receptor internalization. Although CCL2 is primarily a CCR2 ligand, emerging evidence suggests possible
V. S. Davydenko, Alexandr N. Schemelev, Y. V. Ostankova, E. V. Anufrieva, A. A. Totolian   +4 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Treatment With Ruxolitinib and TAK‐779 Enhances GII.17 Human Norovirus Replication and Enables Serial Passaging in Human Intestinal Enteroids

Genes to Cells, Volume 31, Issue 5, September 2026.
We aimed to establish a simple method for GII.17 human norovirus (HuNoV) replication and serial passaging using wild‐type J2 human intestinal enteroids (HIEs). Treatment with ruxolitinib and TAK‐779, which target interferon and chemokine signaling, respectively, enhances viral replication and enables serial passaging of GII.17. ABSTRACT Human norovirus
Eri Hiraishi, Tsuyoshi Hayashi, Yoshiki Fujii, Hirokazu Kimura, Kosuke Murakami   +4 more
wiley   +1 more source

Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage [Elektronisk resurs] [PDF]

, 2007
Popular Abstract in Swedish Människan är uppbyggd av ett stort antal celler. För att kroppens olika organ ska kunna samverka och för att kroppen ska kunna fungera som en helhet, måste de olika cellerna kommunicera med varandra.
Antonsson, Liselotte,, Lund University.
core  

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

The ?32 deletion of CCR5 receptor in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1998
S P, Cooke, G, Forrest, P J, Venables, A, Hajeer   +3 more
openaire   +2 more sources

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Intragenus (Homo) variation in a chemokine receptor gene (CCR5)

PLOS ONE, 2018
Humans have a comparatively higher rate of more polymorphisms in regulatory regions of the primate CCR5 gene, an immune system gene with both general and specific functions. This has been interpreted as allowing flexibility and diversity of gene expression in response to varying disease loads.
openaire   +4 more sources