Results 131 to 140 of about 33,714 (244)
The Puzzling Role of CXCR4 in Human Immunodeficiency Virus Infection
Theranostics, 2013 The human immunodeficiency virus type-1 (HIV-1) is the etiological agent of the acquired immunodeficiency syndrome (AIDS), a disease highly lethal in the absence of combination antiretroviral therapy. HIV infects CD4+ cells of the immune system (T cells,
Elisa Vicenzi, Pietro Liò, Guido Poli
doaj
Quantitative phosphoproteomic profiling of CCL5/CCR5 signaling cascade in melanoma cells
Frontiers in OncologyBackgroundThe CCL5/CCR5 axis plays a pivotal role in tumor progression and metastasis. We previously reported CCR5 promoted melanoma EMT and metastasis by upregulating TGFβ1 expression via the PI3K/AKT/GSK3β pathway.
Lifen Xie +9 more
doaj +1 more source
Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1
The FEBS Journal, EarlyView.Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka +10 more
wiley +1 more source
Genetics of the immune cell receptors TCRB and CCR5 in human disease [PDF]
, 2003 Early in the evolution of the vertebrates it is thought that two genomic duplications occurred, providing a basis for the evolution in body plan and neural crest of very early vertebrates and substantive material for further evolution of various gene ...
Buhler, Marc McWilliams
core
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
Frequency of CCR5?32 Variant in North-West of Iran [PDF]
Journal of Sciences, Islamic Republic of Iran, 2009 Chemokine and chemokine receptors show several variations which may affect resistance to infectious disease. A 32 base pair deletion in the open reading frame of the human CCR5 gene (CCR5?32) results in producing a truncated antigen which fails to be ...
D. Omrani
doaj
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source
Brazilian Journal of Infectious Diseases, 2003 Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including
Munerato Patrícia +7 more
doaj
CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands. [PDF]
Int J Mol Sci, 2020 Korbecki J +4 more
europepmc +1 more source
Immunology &Cell Biology, EarlyView.This study found that BLIMP‐1 is highly expressed in activated effector/memory human regulatory T cells, especially CD39+ Tregs, where it is associated with increased IL‐10 production and a conserved phenotype across blood and lung tissues during immune responses such as SARS‐CoV‐2 infection.
Chansavath Phetsouphanh +10 more
wiley +1 more source