Results 21 to 30 of about 275,691 (287)

On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies

STAR Protocols, 2023
Summary: Chemokine receptors, a subfamily of G-protein-coupled receptors (GPCRs), are responsible for cell migration during physiological processes as well as in diseases like inflammation and cancers.
Siyi Gu, Mian Huang, Tracy M. Handel
doaj   +1 more source

Nuclear Factor-Kappa B Regulation of Osteoclastogenesis and Osteoblastogenesis [PDF]

Endocrinology and Metabolism, 2023
Maintenance of skeletal integrity requires the coordinated activity of multinucleated bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts form resorption lacunae on bone surfaces in response to cytokines by fusion of precursor cells ...
Brendan F. Boyce, Jinbo Li, Zhenqiang Yao, Lianping Xing   +3 more
doaj   +1 more source

Blocking Chemokine Receptors [PDF]

The Journal of Experimental Medicine, 1997
In our first review on chemokines (([1][1])), we suggested that blockade of the IL-8 receptor or inhibition of IL-8 gene expression could be a new principle for designing antiinflammatory agents. The unexpected growth of the chemokine family and consequent redundancy of the system eventually made ...
M, Baggiolini, B, Moser
openaire   +2 more sources

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

CHEMOKINE RECEPTORS [PDF]

Biomedical Papers, 2000
Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamily of rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve as coreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation.
openaire   +2 more sources

A Scintillation Proximity Assay for Real-Time Kinetic Analysis of Chemokine–Chemokine Receptor Interactions

Cells, 2022
Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle, Martin Gustavsson   +1 more
doaj   +1 more source

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

Frontiers in Immunology, 2023
Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska, Giulia D’Uonnolo, Giulia D’Uonnolo, Rafael Luís, Rafael Luís, Rafael Luís, Ana Alonso Bartolomé, Ana Alonso Bartolomé, Marcus Thelen, Daniel F. Legler, Andy Chevigné   +10 more
doaj   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source