Results 1 to 10 of about 30,055 (235)

Radiolabelled peptides for oncological diagnosis [PDF]

, 2012
Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy.
Peter Laverman, Jane K. Sosabowski, Otto C. Boerman, Wim J. G. Oyen   +3 more
core   +1 more source

Review: Free fatty acid receptors: emerging targets for treatment of diabetes and its complications

Therapeutic Advances in Endocrinology and Metabolism, 2010
Fatty acids (FAs) are important as metabolic substrates and as structural components of biological membranes. However, they also function as signalling molecules.
R. Lee Kennedy, Venkat Vangaveti, Ghassan Jarrod, Venkatesh Shashidhar, Venkatesh Shashidhar, Bernhard T. Baune   +5 more
doaj   +1 more source

Activation of Spinal Cholecystokinin and Neurokinin-1 Receptors Is Associated With the Attenuation of Intrathecal Morphine Analgesia Following Electroacupuncture Stimulation in Rats

Journal of Pharmacological Sciences, 2007
We previously demonstrated that electroacupuncture (EA) stimulation both produced antinociception and attenuated intrathecal (i.t.) morphine analgesia, suggesting that EA is capable of inducing two opposing systems, that is, opioid and anti-opioid ...
Yohji Fukazawa, Takehiko Maeda, Norikazu Kiguchi, Kazuo Tohya, Michio Kimura, Shiroh Kishioka   +5 more
doaj   +1 more source

Radiolabeled CCK/gastrin peptides for imaging and therapy of CCK2 receptor-expressing tumors [PDF]

, 2010
Cholecystokinin (CCK) receptors are overexpressed in numerous human cancers, like medullary thyroid carcinomas, small cell lung cancers and stromal ovarian cancers.
Susan Roosenburg, Peter Laverman, Floris L. van Delft, Otto C. Boerman, L Aloj, L Aloj, MP Béhé, MP Béhé, MP Béhé, TM Behr, TM Behr, TM Behr, WAP Breeman, M Jong de, S Luca De, I Dijkgraaf, J Fichna, M Foucaud, AC Fröberg, S Good, M Gotthardt, R Haubner, MR Hellmich, A Imdahl, RB Innis, AC Ivy, AS Kopin, DJ Kwekkeboom, P Laverman, P Laverman, HR Maecke, SJ Mather, Y Matsumori, F Noble, F Noble, BA Nock, JA O’Donoghue, JC Reubi, J-C Reubi, J-C Reubi, H Sankaran, JP Smith, JR Upp Jr, JJ Vanderhaeghen, E Guggenberg von, SA Wank, SA Wank   +46 more
core   +1 more source

Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats

Molecular Pain, 2005
Neonatal noxious insult produces a long-term effect on pain processing in adults. Rats subjected to carrageenan (CAR) injection in one hindpaw within the sensitive period develop bilateral hypoalgesia as adults.
Dubner Ronald, He Fang, Novikova Svetlana I, Ren Ke, Lidow Michael S   +4 more
doaj   +1 more source

Activation of multiple receptors stimulates extracellular vesicle release from trophoblast cells

Physiological Reports, 2020
Reports of the stimulated release of extracellular vesicles (EVs) are few, and the mechanisms incompletely understood. To our knowledge, the possibility that the activation of any one of the multitudes of G‐protein‐coupled receptors (GPCRs) expressed by ...
Kirk P. Conrad, Kubra M. Tuna, Cathleen T. Mestre, Esha S. Banwatt, Abdel A. Alli   +4 more
doaj   +1 more source

Cholecystokinin: an excitatory modulator of mitral/tufted cells in the mouse olfactory bulb. [PDF]

PLoS ONE, 2013
Cholecystokinin (CCK) is widely distributed in the brain as a sulfated octapeptide (CCK-8S). In the olfactory bulb, CCK-8S is concentrated in two laminae: an infraglomerular band in the external plexiform layer, and an inframitral band in the internal ...
Jie Ma, Luba Dankulich-Nagrudny, Graeme Lowe   +2 more
doaj   +1 more source

Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor [PDF]

The Journal of Neuroscience, 2005
Orexin A and B are neuropeptides implicated in the regulation of sleep/wakefulness and energy homeostasis. The regulatory mechanism of the activity of orexin neurons is not precisely understood. Using transgenic mice in which orexin neurons specifically express yellow cameleon 2.1, we screened for factors that affect the activity of orexin neurons (a ...
Natsuko, Tsujino, Akihiro, Yamanaka, Kanako, Ichiki, Yo, Muraki, Thomas S, Kilduff, Ken-ichi, Yagami, Satoru, Takahashi, Katsutoshi, Goto, Takeshi, Sakurai   +8 more
openaire   +2 more sources

Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: The spontaneous preference for dietary lipids is principally regulated by 2 lingual fat taste receptors, CD36 and GPR120. Obese animals and most of human subjects exhibit low orosensory perception of dietary fat because of ...
Amira Sayed Khan, Aziz Hichami, Babar Murtaza, Marie-Laure Louillat-Habermeyer, Christophe Ramseyer, Maryam Azadi, Semen Yesylevskyy, Floriane Mangin, Frederic Lirussi, Julia Leemput, Jean-Francois Merlin, Antonin Schmitt, Muhtadi Suliman, Jérôme Bayardon, Saeed Semnanian, Sylvain Jugé, Naim Akhtar Khan   +16 more
doaj   +1 more source

Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder

European Psychiatry, 2022
Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva, T. Syunyakov, M. Metlina, N. Ivashkina   +3 more
doaj   +1 more source