Results 211 to 220 of about 142,291 (304)

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

Molecular mechanisms and therapeutic implications of the sympathetic nervous system in bone-related disorders: a brain-bone axis perspective. [PDF]

Bone Res
Liu M, Liu Y, Yu J, Gong J, Zhao C, Liu Z.   +5 more
europepmc   +1 more source

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng, Jennifer Nolz, Timothy Karr, Nicole Dorn, Benjamin Readhead, Rosa Krajmalnik‐Brown, Diego Mastroeni   +6 more
wiley   +1 more source

Relationship of cholinergic basal forebrain atrophy with the time course of Alzheimer's disease pathology and cognitive decline in adults with Down syndrome: a longitudinal cohort study

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Adults with Down syndrome (DS) display increased Alzheimer's disease (AD) risk. The cholinergic system declines early in the AD continuum and relates to cognitive and functional decline. We aimed to identify the timeline of cholinergic decline in relation to hippocampal atrophy within the AT(N) framework in DS.
Jason K. Russell, Zinayida Schlachetzki, Alexander C. Conley, Brian D. Boyd, Paul A. Newhouse, Paul S. Aisen, Michael S. Rafii, for the Alzheimer's Biomarker Consortium on Down Syndrome Study   +7 more
wiley   +1 more source

GM1 and GD3 Gangliosides Attenuate Diisopropylfluorophosphate-Induced NGF-TrkA and BDNF-TrkB Signaling Dysfunction. [PDF]

ACS Chem Neurosci
Itokazu Y, Beck WD, Terry AV.
europepmc   +1 more source

Six‐month follow‐up of ARIA‐H and iron deposition in real‐world lecanemab therapy for Alzheimer's disease: Evidence from a Chinese 7T MRI cohort

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION With the approval of lecanemab for treating Alzheimer's disease (AD), there is an urgent need to evaluate its safety and treatment effects on biomarkers in real‐world practice. METHODS Patients receiving lecanemab (n = 72) underwent routine 3T and 7T magnetic resonance imaging (MRI) for amyloid‐related imaging abnormality (ARIA ...
Weiwei Zhang, Haokun Liu, Cong Zhang, Yulai Li, Keying Fang, Yafang Zhou, Ling Weng, Liangjuan Fang, Yingying Luo, Han Xiao, Lin Zhou, Bin Jiao, Lu Shen   +12 more
wiley   +1 more source

Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia. [PDF]

J Nanobiotechnology
Zhang M, You T, Guo M, Zhao Y, Shen W, Wang Y, Jiang Y, Dong Q, Yu J, Cui M, Zhao Y.   +10 more
europepmc   +1 more source

Association between basal forebrain volume and age in the presenilin‐1 E280A autosomal dominant Alzheimer's disease kindred

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION The basal forebrain (BF), a key cholinergic hub, undergoes atrophy in Alzheimer's disease (AD), contributing to cognitive decline. However, its age‐related differences and early vulnerability in autosomal dominant AD (ADAD) remain unclear.
Bing He, Paula Ospina Lopera, Alejandro Espinosa, Juan Camilo Becerra, Laura Osorio, Diana Alzate, Sergio Alvarez, Alice Grazia, Stefan J. Teipel, Vincent Malotaux, Catarina Tristão‐Pereira, Meredith C. Rowe, Averi Giudicessi, Yi Su, Yinghua Chen, Sonia Do Carmo, David Aguillón, A. Claudio Cuello, Yakeel T. Quiroz   +18 more
wiley   +1 more source

Neurexin regulates mechanical nociceptive sensitization by central inhibition in <i>Drosophila</i>. [PDF]

Sci Adv
Meng Z, Geng J, Sun Y, Xu L, Zhao Y, Ou M, Wang Y, Han J, Gu P, Xie W.   +9 more
europepmc   +1 more source