Results 221 to 230 of about 2,364,275 (293)

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

A phase 0, window of opportunity study of parasympathetic stimulation with bethanechol in localized pancreatic adenocarcinoma prior to surgery. [PDF]

Oncologist
White RA, Mezzano-Robinson V, Shi Q, Kuriakose N, Schrope B, Kluger MD, Sugahara K, Chabot J, Manji G, Oberstein P, Remotti H, Wang TC, Bates SE.   +12 more
europepmc   +1 more source

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The Down syndrome‐associated Alzheimer's disease (DSAD) autosomal dominant Alzheimer's disease (ADAD) 2024 Conference in Barcelona, convened under an Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) grant through the Down syndrome and Alzheimer's disease (AD) Professional ...
Neus Falgàs, Lucia Maure‐Blesa, Beau Ances, Lisi Flores‐Aguilar, Sigan Hartley, Jason Hassenstab, M Florencia Iulita, Matthew Janicki, Katherine Koenig, Patrick Lao, Johannes Levin, Eric McDade, Laurent Meijer, Michael S. Rafii, Heather M. Snyder, Raquel Sánchez‐Valle, Juan Fortea, DSAD‐ADAD conference group, Jose Arriola Infante, Mirea Balasa, Isabel Barroeta, Nicolas Barthelemy R, Alexandre Bejanin, Bessy Benejam, Beatriz Bosch, Angela Bradshaw, Maria Carmona‐Iragui, Ann Cohen, Aina Comas Albertí, Lajos Csincsik, A. Claudio Cuello, Laura del Hoyo Soriano, Janna Dijkstra, Natalie Edwards, Sandra Giménez, Fernando Gonzalez‐Ortiz, Brian Gordon, Sara Gutiérrez Fernández, Benjamin Handen, Charlotte Jacob, Erik Johnson, Charlotte Johansson, Albert Lladó, Alberto Lleó, Samuel Morabito, Alejandra. O. Morcillo‐Nieto, Laia Montoliu‐Gaya, Michael Okafor, Agnes Pérez‐Millan, Marie Claude Potier, John Ringman, Íñigo Rodríguez‐Baz, Eric Rubenstein, Natalie S. Ryan, André Strydom, Lidia Vaqué‐Alcázar, Lisa Vermunt, Laura Videla Toro, Shahid Zaman   +58 more
wiley   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

Arthritis &Rheumatology, Volume 77, Issue 7, Page 901-913, July 2025.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries‐Bouwstra, Laura H. Heitman, Cynthia M. Fehres   +8 more
wiley   +1 more source

Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward. [PDF]

Front Mol Neurosci
Fritz M, Rosa PB, Wilhelms D, Jaarola M, Ruud J, Engblom D, Klawonn AM.   +6 more
europepmc   +1 more source

The Therapeutic Effects of Acorus Tatarinowii Volatile Oil and Electroacupuncture in Post‐Stroke Cognitive Impairment Patients: A Clinical Trial Protocol

Brain and Behavior, Volume 15, Issue 7, July 2025.
Conceptual schematic illustrating the trial design and mechanisms. Electroacupuncture (EA) targets cervical acupoints (GB20/Gongxue) to improve cerebral blood flow and neural connectivity. HOT (herbal olfactory therapy) delivers Acorus Tatarinowii volatile oil via inhalation to penetrate the blood‐brain barrier, reduce neuroinflammation, and enhance ...
Ying Dandan, Zhao Jingting, Wang Minzhe, Cai Zhuoyue, Li Xinyun   +4 more
wiley   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases. [PDF]

Orthop Surg
Xia R, Peng H, Zhu X, Suolang W, Pambayi STL, Yang X, Zeng Y, Shen B.   +7 more
europepmc   +1 more source

Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS

Glia, Volume 73, Issue 7, Page 1365-1382, July 2025.
Main Points In the Drosophila PNS, motor‐ and sensory axons differentially interact with wrapping glia processes. Sensory axons are more weakly associated with wrapping glia and show a length dependent degeneration upon loss of wrapping glia. ABSTRACT In vertebrates, there is a differential interaction between peripheral axons and their associated ...
Steffen Kautzmann, Simone Rey, Amber Krebs, Christian Klämbt   +3 more
wiley   +1 more source