Results 1 to 10 of about 185,548 (244)

Structural biology of complement receptors

Frontiers in Immunology, 2023
The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer.
Jorge Santos-López, Karla de la Paz, Karla de la Paz, Francisco J. Fernández, M. Cristina Vega   +4 more
doaj   +3 more sources

Biomimetic carbon nanopolymers ANM-NPs act on mannose receptors and complement receptors to promote tumor antigen presentation [PDF]

Journal for ImmunoTherapy of Cancer
Background Enhancing immunogenicity and antigen-presentation efficiency is critical for tumor vaccine development. While yeast-surface glycoprotein side chains can improve antigen presentation, their ability to deliver tumor antigens remains limited ...
Lei Zhang, Tao Sun, Heng Zhang, Yujie Sun, Yi-Nan Li, Huijuan Liu, Zhuangzhuang Feng, Xinxiu Shi, Zhiyang Li, Minming Lou, Bijia Cui, Mengzhan Chen   +11 more
doaj   +2 more sources

Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis

Frontiers in Cell and Developmental Biology, 2021
The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Sofie Vandendriessche, Seppe Cambier, Paul Proost, Pedro E. Marques   +3 more
doaj   +1 more source

An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer

Antibodies, 2021
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir, Mohd Hezmee Mohd Noor, Keith Weng Kit Leong, Jamileh A. Nabizadeh, Helga D. Manthey, Stefan E. Sonderegger, Jenny Nga Ting Fung, Crystal E. McGirr, Ian A. Shiels, Paul C. Mills, Trent M. Woodruff, Barbara E. Rolfe   +11 more
doaj   +1 more source

Helix 8 in chemotactic receptors of the complement system.

PLoS Computational Biology, 2022
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski, Paulina Dragan, Anna Makal, Dorota Latek   +3 more
doaj   +1 more source

Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

iScience, 2023
Summary: Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD.
Ai Na Ng, Eric W. Salter, John Georgiou, Zuner A. Bortolotto, Graham L. Collingridge   +4 more
doaj   +1 more source

Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy

Molecular Therapy: Methods & Clinical Development, 2023
High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved ...
Michael R. Emami, Alejandro Espinoza, Courtney S. Young, Feiyang Ma, Philip K. Farahat, Philip L. Felgner, Jeffrey S. Chamberlain, Xiangmin Xu, April D. Pyle, Matteo Pellegrini, S. Armando Villalta, Melissa J. Spencer   +11 more
doaj   +1 more source

The many roles of C1q

eLife, 2020
The ability of a well-known component of the complement cascade to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Mark Noble, Christoph Pröschel
doaj   +1 more source

Receptor-Mediated NETosis on Neutrophils

Frontiers in Immunology, 2021
Neutrophil extracellular traps (NETs), a web-like structures containing chromatin, have a significant role in assisting the capture and killing of microorganisms by neutrophils during infection.
Tao Chen, Tao Chen, Tao Chen, Yanhong Li, Yanhong Li, Yanhong Li, Rui Sun, Rui Sun, Rui Sun, Huifang Hu, Huifang Hu, Huifang Hu, Yi Liu, Yi Liu, Yi Liu, Martin Herrmann, Yi Zhao, Yi Zhao, Yi Zhao, Luis E. Muñoz   +19 more
doaj   +1 more source

Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

Antioxidants, 2020
The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly   +6 more
doaj   +1 more source