Results 61 to 70 of about 14,486 (179)

Dual‐Laser Laser‐Induced Liquid Bead Ion Desorption Mass Spectrometry: A New Approach for Adjustable Softness and Higher Sensitivity

ChemPhysChem, Volume 27, Issue 14, 29 July 2026.
Native protein complexes often require gentle ionization to preserve weak interactions, yet higher ion yield typically goes hand in hand with increased in‐source dissociation. Our dual‐laser LILBID approach decouples ion production from dissociation by using two independently tunable pulses, enabling sample‐specific soft conditions and expanding access
Niko Popovic, Jonathan Schulte, Anne Mayer, Clemens Glaubitz, Nina Morgner   +4 more
wiley   +1 more source

Chemo‐Immunotherapy, a Combination Approach for the Treatment of HER2‐Positive Breast Cancer in a Mouse Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
Experimental workflow of HER2/Neu‐targeted dendritic cell‐based chemo‐immunotherapy in a 4T1‐HER2 breast cancer xenograft model. ABSTRACT The discovery of tumor‐associated antigens has been a significant milestone for cancer therapy as the current conventional therapies (radiotherapy, chemotherapy) were found to be insufficient in terms of cancer ...
Cenk Serhan Özverel, Kubilay Doğan Kılıç, Yiğit Uyanikgil, İsmail Karaboz, Ayse Nalbantsoy   +4 more
wiley   +1 more source

Pam3CSK4 As a Second Hit in NLRP3‐Dependent Activation of Monocytes Primed With Antiphospholipid Antibodies

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Pam3CSK4 amplifies aPL‐induced monocyte activation. This results in thromboinflammatory activation that may contribute to APS‐related vascular pathology. ABSTRACT Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection‐induced exacerbation of
Anush Martirosyan, Eva Kriegova, Jana Ulehlova, Zaven Karalyan, Tomas Papajik, Gayane Manukyan   +5 more
wiley   +1 more source

Alliinase: A Comprehensive Review of the Pivotal Enzyme in Garlic Chemistry and Its Applications

Food Frontiers, Volume 7, Issue 4, July 2026.
Garlic crude extract was purified to obtain alliinase, which catalyzes alliin hydrolysis to release allicin. The free and immobilized alliinase shows potential applications in food, biotechnology, pharmaceuticals, health products, and biosensors. ABSTRACT Alliinase is a pyridoxal 5′‐phosphate (PLP)‐dependent lyase that serves as the cornerstone of the ...
Zhenlin Han, Tian Ye, Yantian Tang, Guodong Su, Jiazhou Li, Ningyang Li   +5 more
wiley   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Eliminating PD‐L1 on Dendritic Cell Extracellular Vesicles for Immunotherapy Potentiates Immune‐Mediated Tumour Rejection in Mice

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Extracellular vesicles (EVs) for immune therapy of cancer have both direct and indirect effects on immune cells. When taken up, the loaded antigen is presented by the host's dendritic cells (indirect). In this case, EV surface molecules like MHC‐peptide complexes on EVs are of minor importance. Here we show that removal of PD‐L1 from the surface of EVs
Loes Teeuwen, Loïc Steiner, Chantal Reinhardt, Annemarijn Offens, Jesse E. Kuipers, Daniel Martínez‐Martínez, Jules Mazouin, Benedict J. Chambers, Gözde Güçlüler Akpinar, Susanne Gabrielsson   +9 more
wiley   +1 more source

Diacetylene‐Functionalized Glycan Mimetics for Receptor‐Mediated Cluster Imprinting in Model Membranes

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Diacetylene‐containing glycan mimetics cluster upon selective lectin binding in GUVs. Subsequent irradiation leads to the formation of fluorescent polymer clusters, while non‐clustered glycan mimetics remain unaffected in the membrane. ABSTRACT The glycocalyx, a dense layer of glycoproteins and glycolipids on eukaryotic cells, is essential for cellular
Luca‐Cesare Blawitzki, Lina Charlotte Assenmacher, Nicholas Jäck, Stephan Schmidt, Cornelia Monzel, Laura Hartmann   +5 more
wiley   +1 more source

Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells

Biomolecules
Special attention is given to cow’s milk and its variants, with ongoing discussions about health-related impacts primarily focusing on the A1 variant in contrast to the A2 variant.
Felix Gard, Lili M. Flad, Tanja Weißer, Hermann Ammer, Cornelia A. Deeg   +4 more
doaj   +1 more source

Scotty: lattice coincidences for macromolecular crystallographic phasing

Acta Crystallographica Section D, Volume 82, Issue 7, Page 813-823, July 2026.
Scotty is a tool that leverages Niggli‐cell matches to identify similar crystallographic lattices and perform phasing with difference Fourier methods.When a macromolecular crystal lattice targeted for study is closely related to a previously studied crystal lattice, phasing the target crystal by difference (fast‐)Fourier transform (DFFT) methods is ...
Airlie J. McCoy, Lawrence C. Andrews, Herbert J. Bernstein, Randy J. Read   +3 more
wiley   +1 more source

Super‐Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non‐Cancerous Tissues

Cancer Science, Volume 117, Issue 7, Page 1894-1906, July 2026.
While CAFs are produced as a result of education by cancer cells in non‐scirrhous gastric cancer, normal fibroblasts of scirrhous gastric cancer patients are already pre‐conditioned, forming a stromal field for scirrhous gastric cancer. ABSTRACT Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer ...
Yoshimi Yasukawa, Naoko Hattori, Yu‐Yu Liu, Masayuki Tobo, Genki Yamagishi, Takahiro Irie, Shigeki Sekine, Tohru Kiyono, Satoshi Yamashita, Yukinori Yamagata, Takaki Yoshikawa, Yasuyuki Seto, Toshikazu Ushijima   +12 more
wiley   +1 more source