Results 61 to 70 of about 26,449 (216)

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice

open access: yesFrontiers in Immunology, 2019
Activation of the innate immune system, including tissue macrophages and associated neutrophil infiltration, is an important driver of subsequent adaptive immune responses in many autoimmune diseases, including autoimmune hepatitis (AIH).
Wagdi Almishri   +3 more
doaj   +1 more source

Inhibition of intercellular adhesion by concanavalin A is associated with concanavalin A-mediated redistribution of surface receptors. [PDF]

open access: yesThe Journal of cell biology, 1979
The inhibition of adhesion between aggregates and layers of embryonic retinal cells by concanavalin A (Con A) and Con A-mediated rearrangements of Con A receptors on retinal cells were studied. A short incubation of aggregates and layers with 10 micrograms/ml Con A substantially reduced aggregate-to-layer adhesion in a subsequent assay without soluble ...
openaire   +2 more sources

Valorization of Yacon (Smallanthus sonchifolius) peel for peroxidase production and its immobilization on alginate beads for 2,4‐dichlorophenol bioconversion

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Sodium alginate was modified with EDC/NHS for the immobilization of Yacon peel peroxidase, resulting in a novel biocatalyst for the oxidation of 2,4‐dichlorophenol. Abstract Yacon (Smallanthus sonchifolius) roots are emerging as an alternative source of peroxidase. This study aimed to extract, immobilize, and characterize the peroxidase from Yacon peel,
Mariana Gomes Oliveira   +4 more
wiley   +1 more source

The effect of concanavalin A on the replication of rotavirus (SA-11) in cell culture

open access: yesBrazilian Archives of Biology and Technology, 2002
Rotavirus (RV) strain SA-11 was studied with respect to its infectivity in MA-104 cell cultures and the effect of concanavalin A (ConA). Receptors for ConA at the surface of MA-104 cell were determined by fluorescence assay and specifically inhibited by ...
Hasenack Beatriz S.   +7 more
doaj  

Dopamine D2 Receptor-Mediated AKT/PKB Signalling: Initiation by the D2S Receptor and Role in Quinpirole-Induced Behavioural Activation

open access: yesASN Neuro, 2012
The short and long isoforms of the dopamine D2 receptor (D2S and D2L respectively) are highly expressed in the striatum. Functional D2 receptors activate an intracellular signalling pathway that includes a cAMP-independent route involving Akt/GSK3 ...
Han-Ting Chen   +3 more
doaj   +1 more source

Modulation of human lymphocyte function by C3a and C3a(70-77). [PDF]

open access: yes, 1982
Human C3a and the synthetic octapeptide C3a (70-77), which retains the activities of an anaphylatoxin, inhibit in a concentration-dependent manner the generation of leukocyte inhibitory factor (LIF) activity by human mononuclear leukocytes and T ...
Goetzl, EJ, Payan, DG, Trentham, DE
core  

Molecular Physiology of Kainate Receptors [PDF]

open access: yes, 2001
28 páginas, 15 figuras, 3 tablas.A decade ago, our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology was essentially null.
Lerma Gómez, Juan   +3 more
core   +1 more source

Capacity of different cell types to stimulate cytotoxic T lymphocyte precursor cells in the presence of interleukin 2 [PDF]

open access: yes, 1984
Plastic-adherent cells enriched for dendritic cells (AC) were found to be among the most potent stimulator cells for the activation of cytotoxic T lymphocytes (CTL) in vitro in the presence of interleukin 2 (IL 2) and a constant second set of allogeneic ...
Dröge, W.   +6 more
core  

pH-Degradable mannosylated nanogels for dendritic cell targeting [PDF]

open access: yes, 2016
We report on the design of glycosylated nanogels via core-cross linking of amphiphilic non-water-soluble block copolymers composed of an acetylated glycosylated block and a pentafluorophenyl (PFP) activated ester block prepared by reversible addition ...
Ayres, Neil   +12 more
core   +2 more sources

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

open access: yesiNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen   +6 more
wiley   +1 more source

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