Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature [PDF]
, 2011 Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases and have a limited efficacy in the treatment of metastatic disease.
J. PosthumaDeBoer +3 more
core +1 more source
From Heterogeneity to Plasticity: Endothelial Dynamics in Lung Disease
Pulmonary Circulation, Volume 16, Issue 2, June 2026.ABSTRACT Endothelial heterogeneity and plasticity play an important role in lung development, homeostasis, and pathology. In recent years, increasing evidence has demonstrated that endothelial dysfunction contributes to the progression of various lung diseases, such as ADRS, PF, PH, and lung developmental disorders.
Van Dung Nguyen, Bisheng Zhou
wiley +1 more source
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
, 2011 Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L +4 more
core +1 more source
Galectin‐9high Neutrophils Exacerbate Radiation‐Induced Frailty
Aging Cell, Volume 25, Issue 4, April 2026.EccDNA shedding after skin radiation injury activates the JAK1/2‐STAT1 pathway in splenic GMP cells to induce the production of GAL‐9high neutrophils. This unique population of hyperactive GAL‐9high neutrophils is identified with characteristics of elevated NETs and IFN‐γ, etc.
Zhuo Cheng +13 more
wiley +1 more source
Global Spine Journal, 2014 Introduction Degenerative disc disease (DDD) is a prevalent musculoskeletal disorder and is the major cause of low back pain. But our comprehension about development of the intervertebral disc (IVD) and pathogenesis of disc degeneration is unclear, which
C. Feng
doaj +1 more source
Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]
, 2017 Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin +10 more
core +3 more sources
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi +11 more
wiley +1 more source
Computational design of anti-cancer peptides tailored to target specific tumor markers
BMC ChemistryAnti-cancer peptides (ACPs) are short peptides known for their ability to inhibit tumor cell proliferation, migration, and the formation of tumor blood vessels.
Aisha Naeem +4 more
doaj +1 more source
Chronic lymphocytic leukemia: insights from lymph nodes & bone marrow and clinical perspectives [Kronična limfocitna leukemija: uvidi iz limfnog čvora i koštane srži i kliničke perspektive] [PDF]
, 2010 B-cell chronic lymphocytic leukemia (B-CLL) is characterized by highly variable distribution of tumor mass between peripheral blood, bone marrow and lymphoid organs which is important for staging, classification and prognosis.
Jakšić, Branimir +2 more
core
CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL. [PDF]
, 2017 Tumor-infiltrating neutrophils have been implicated in malignant development and progression, but mechanisms are ill defined. Neutrophils produce a proliferation-inducing ligand APRIL/TNFSF13, a factor that promotes development of tumors from diverse ...
Callanan, M. +13 more
core +2 more sources