Results 81 to 90 of about 11,764 (203)

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Advanced Science, Volume 13, Issue 19, 2 April 2026.
CXCR4 functions as a potential cancer stem cell‐associated marker linked to chemoresistance in ovarian cancer, and an inhibitor of CXCR4, AMD3100, can enhance the cytotoxic response to cisplatin. Based on these findings, [68Ga]Ga‐Pentixafor positron emission tomography enables selective visualization of CXCR4‐high ovarian cancer, while AMD3100 combined
Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang, Feiquan Ying, Lin Huang, Mengna Zhu, Mengqing Chen, Qiang Yang, Si Sun, Dawei Jiang, Lingling Gao, Jing Cai   +12 more
wiley   +1 more source

Chemokine receptor hetero-oligomers regulate monocyte chemotaxis

Life Science Alliance
Many chemokine receptors in human monocytes function within hetero-oligomeric complexes with α 1 -adrenoceptors and arginine vasopressin receptor 1A through which the chemokine receptor heteromerization partners are regulated.
Garrett A Enten, Xianlong Gao, Michelle Y McGee, McWayne Weche, Matthias Majetschak   +4 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis [PDF]

Andrology, 2013
SummarySeminoma and non‐seminoma tumours increasingly occur within the western population. These tumours originate from carcinoma in situ (CIS) cells, which arise from dysfunctional gonocytes. CXCL12 and its receptors, CXCR4 and CXCR7, have been implicated in migration, proliferation and survival of gonocytes and their precursors and progeny ...
McIver, Skye C., Loveland, Kate L., Roman, Shaun D., Nixon, Brett, Kitazawa, Riko, McLaughlin, Eileen A. (R19932)   +5 more
openaire   +3 more sources

Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis

BioEssays, Volume 48, Issue 4, April 2026.
How collective cell migration starts and stops is a fundamental question but remains poorly understood. This review discusses the distinct mechanisms in in vivo models and cancer metastasis that define the regulatory pathways and collective features governing the initiation and termination of collective cell migration.
Guangxia Miao
wiley   +1 more source

Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver [PDF]

, 2015
Leukocyte adhesion and transmigration are central features governing immune surveillance and inflammatory reactions in body tissues. Within the liver sinusoids, chemokines initiate the first crucial step of T-cell migration into the hepatic tissue.
A Dar, A Erhardt, A Hamann, A Hayer, A Rot, A Schrage, A Schrage, AJ Hoogewerf, Alexander Scheffold, Anja A. Kühl, B Moser, C Chen, C Gerard, C Murdoch, CE Harvey, CT Okamoto, E Mordelet, EC Butcher, EL Eskelinen, ES Baekkevold, F Marra, GA Donzella, H Kobayashi, I Mellman, IA Khan, J Middleton, JJ Campbell, JJ Maher, JL Goldstein, K Arai, K Ikeda, K Ley, K Neumann, Katja Klugewitz, Katja Wechsung, Katrin Neumann, KF Yoong, KG Rothberg, KJ Livak, L Wang, LH Wang, M Baggiolini, M Heydtmann, M Meyer, M Pruenster, M Zeremski, Michael Schumann, N Signoret, Nils Kruse, O Wald, P Tuma, PF Lalor, PJ MacPhee, PL Shields, R Shamri, Rene Lutter, RF Schwabe, S Christoforidis, S Ge, S Goddard, S Shetty, SM Curbishley, T Stroh, Ulrike Erben, W Yang, WW Hancock, WY Lee, Y Tanaka, YH Oo, YH Oo   +69 more
core   +3 more sources

The Effects and Mechanisms of Pomegranate on Regulating Lipid Metabolism

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study established a high‐fat diet‐induced hyperlipidemia rat model to investigate the lipid‐lowering effects of pomegranate. Pomegranate intervention significantly reduced serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) levels, while alleviating hepatic steatosis by decreasing liver weight and fat ...
Hao Wang, Jingtao Liu, Xin Dong, Tiantian Shi, Xuena Zhang, Yide He, Shaonan Hu, Yuewu Wang, Jian Zheng, Peifeng Xue   +9 more
wiley   +1 more source

CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry

Virology, 1997
We have assayed a variety of 7tm chemokine receptors (CCR-2b, CCR-3, CCR-4, CCR-5, CXCR-1, CXCR-4) and two orphan 7tm receptors (V28 and EBI.1) for their ability to allow infection of CD4-negative feline kidney CCC cells by the HIV-2 strains ROD/A and ROD/B. We found that ROD/B was able to use CXCR-4 transiently expressed in CCC cells, and infection by
Reeves, Jacqueline D., McKnight, ÁINE, Potempa, Sandra, Simmons, Graham, Gray, Patrick W., Power, Christine A., Wells, Timothy, Weiss, Robin A., Talbot, Simon J.   +8 more
openaire   +2 more sources

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, Volume 40, Issue 4, Page 1970-2002, April 2026.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source