Results 141 to 150 of about 22,074 (250)

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, Volume 178, Issue 4, Page 685-703, August 2026.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

The CXCR3 Binding Chemokine IP-10/CXCL10:  Structure and Receptor Interactions^†

, 2016
The structure of IP-10 was solved by NMR spectroscopy and represents the first structure from the class of agonists toward the receptor CXCR3. CXCR3 binding chemokines are unique in their ability to bind receptors from both the CC and CXC classes of ...
Brian D. Sykes (74912), David W. Keizer (2331394), Valerie Booth (207759), Monique B. Kamphuis (28542), Ian Clark-Lewis (2537932)   +4 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, Volume 16, Issue 7, Page 1244-1258, July 2026.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Physiological Functions of Biased Signaling at the Chemokine Receptor CXCR3

, 2019
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and one of the most common drug targets. It is now well-established that GPCRs can signal through multiple transducers, including heterotrimeric G proteins, G ...
Smith, Jeffrey
core  

Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia

, 2002
It has been established recently that inflammation of the CNS is accompanied by an expression of chemokines within the CNS. Several lines of evidence suggest that chemokines within the CNS initiate and orchestrate the infiltration of the inflamed brain ...
C.J.A De Groot, R.M Ransohoff, Trebst, C, Ransohoff, R M, H.W.G.M Boddeke, De Groot, CJA, Dijkstra, [No Value], K Biber, Biber, K, Ransohoff, RM, I Dijkstra, Boddeke, H W G M, Boddeke, HWGM, C Trebst, Dijkstra, I, de Groot, C J A   +15 more
core   +1 more source

Integrative Multi‐Omics Analysis Reveals the Tumor‐Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer

BioFactors, Volume 52, Issue 4, July/August 2026.
This study identifies SEMA5B as a tumor suppressor in prostate cancer that suppresses the malignant phenotype, affects mitochondrial oxidative metabolism, induces cell cycle arrest and apoptosis, and is associated with the immune‐inflammatory tumor microenvironment, highlighting its potential as a biomarker and target for immunotherapy. ABSTRACT SEMA5B
Zhiguo Fan, Yihaoyun Lou, Xuan Zhou, Guang Liu, Xiaomin Zhang, Yuanjie Tang, Zhen Zhu, Shancheng Ren, Yifan Chang   +8 more
wiley   +1 more source

Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors

, 2008
The chemokine receptor CXCR3 is involved in various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, psoriasis, and allograft rejection in transplantation patients.
Fitzsimons, C.P., de Esch, I.J.P.; id_orcid, Smit, M.J.; id_orcid, Smit, M.J., Zaman, G.J., Scholten, D.J., Pease, J.E., de Esch, I.J.P., Bosch, L., Tensen, C.P., Scholten, D.J.; id_orcid, Reinhart, T.A., Storelli, S., Streblow, D.N., Verzijl, D., Leurs, R.   +15 more
core   +1 more source

Chemokine Receptor CXCR3 Measurement [PDF]

, 2020
openaire   +1 more source

Updates on intratumoral therapies in melanoma

Cancer, Volume 132, Issue 13, 1 July 2026.
Abstract Intratumoral therapies provide an opportunity for novel strategies in the management of advanced melanoma. These approaches deliver concentrated doses of therapeutic immune agents directly into individual tumor(s), achieving local tumor control and induction of systemic antitumor immune responses while minimizing the risk of immune‐related ...
Vincent T. Ma, Alyssa K. Steimle, Janmesh D. Patel, Caroline Burkey, Justin C. Moser, Asad Javed, Hibba tul Rehman, Mustafa Ege Seker, Alexander Birbrair, Orhan S. Ozkan, Mark R. Albertini, Yana G. Najjar, Rajan P. Kulkarni   +12 more
wiley   +1 more source

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source