Results 121 to 130 of about 22,074 (250)

Anemia and erythropoietin in heart failure [PDF]

, 2005
Na een hartinfact krijgen veel patiënten te maken met hartfalen; een verminderde pompfunctie van het hart. Peter van der Meer ontdekte dat EPO de hartfunctie van patiënten kan verbeteren.
Meer, Peter van der,, Meer, Peter van der   +1 more
core  

Mechanisms of Biased Signaling at the Chemokine Receptor CXCR3

, 2023
G protein-coupled receptors (GPCRs) are the most common transmembrane receptors in the human genome and the target of approximately one-third of all approved drugs. GPCRs interact with many transducers like G proteins and β-arrestins.
Eiger, Dylan Scott
core  

Autoantibodies in Serum of Systemic Scleroderma Patients: Peptide-Based Epitope Mapping Indicates Increased Binding to Cytoplasmic Domains of CXCR3

Frontiers in Immunology, 2018
Systemic sclerosis (SSc) is a severe chronic autoimmune disease with high morbidity and mortality. Sera of patients with SSc contain a large variety of autoantibody (aab) reactivities.
Andreas Recke, Andreas Recke, Ann-Katrin Regensburger, Florian Weigold, Antje Müller, Harald Heidecke, Gabriele Marschner, Christoph M. Hammers, Ralf J. Ludwig, Gabriela Riemekasten, Gabriela Riemekasten   +10 more
doaj   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

T Lymphocyte Recruitment into Renal Cell Carcinoma Tissue: A Role for Chemokine Receptors CXCR3, CXCR6, CCR5, and CCR6

, 2011
BACKGROUND: Evidence suggests that some patients with renal cell carcinoma (RCC) respond to immunomodulatory therapies that activate T lymphocytes. A prerequisite for effective T cell therapy is efficient targeting of effector T cells to the tumour site,
Adams, David, Lee, Steven, Oldham, Kimberley, Wallace, DM, Deshmukh, N, Bhatt, Rupesh, Chaudhri, S, Parsonage, Gregory   +7 more
core   +1 more source

Infant respiratory infections modulate lymphocyte homing to breast milk

Frontiers in Immunology
IntroductionChemokines and their receptors are essential for leukocyte migration to several tissues, including human milk. Here, we evaluated the homing of T and B lymphocyte subsets to breast milk in response to ongoing respiratory infections in the ...
Yingying Zheng, Simone Corrêa-Silva, Regina Maria Rodrigues, Eloisa Corrêa de Souza, Fernanda A. Macaferri da Fonseca, Alfredo Elias Gilio, Magda Carneiro-Sampaio, Patricia Palmeira   +7 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

CXCR3 Directs Antigen-Specific Effector CD4+ T Cell Migration to the Lung During Parainfluenza Virus Infection

, 2009
Udgivelsesdato: 2009-Sep-4Effector T cells are a crucial component of the adaptive immune response to respiratory virus infections. Although it was previously reported that the chemokine receptors CCR5 and CXCR3 affect trafficking of respiratory virus ...
Thomsen, Allan R, Roberts, Alan D, Miller, Shannon C, Cookenham, Tres, Woodland, David L, Christensen, Jan P, Kohlmeier, Jacob E   +6 more
core   +1 more source

Computer-aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma. [PDF]

J Cell Mol Med, 2020
Yu X, Lu W, Ng CW, Xu S, Wu Y, Chen S, Gao Y, Zhang Y, Zhang Q, Xu Y, Liu Y, Li S.   +11 more
europepmc   +1 more source