Results 41 to 50 of about 2,396,893 (309)
CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy
Cancers, 2022 Simple Summary Chemokines are small soluble proteins that control and regulate cell trafficking within and between tissues by binding to their receptors.
R. Mezzapelle +8 more
semanticscholar +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 In this preclinical study, we evaluated the efficacy and feasibility of creating broad human immunodeficiency virus (HIV) resistance by simultaneously disrupting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 ...
Shasha Li, Leo Holguin, John C. Burnett
doaj +1 more source
Clinical relevance of chemokine receptor CXCR4
Postępy Higieny i Medycyny Doświadczalnej, 2012 Stromal cell-derived factor-1 (SDF-1/CXCL12) induces intracellular signaling pathways crucial for mobilization, migration, proliferation and survival of many cell types via CXCR4, a chemokine CXC-motif receptor, member of the G protein-coupled receptor family.
Katarzyna, Gębura +1 more
openaire +2 more sources
CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies
International Journal of Molecular Sciences, 2021 Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as C-X-C motif chemokine 12 (CXCL12), a prognostic factor, is an extracellular ...
Tripti Khare, M. Bissonnette, S. Khare
semanticscholar +1 more source
Chemokine Receptor CXCR4 Expression in Endothelium
Biochemical and Biophysical Research Communications, 1998 The expression of chemokine receptor and viral coreceptor CXCR4 is reported in cultured endothelial cells and in arterial endothelium. A 1.9 kb transcript was cloned from cultured bovine aortic (BAEC) and human umbilical vein endothelial cells (HUVEC).
M V, Volin +3 more
openaire +2 more sources
PLoS ONE, 2021 BackgroundActivation of intravesical protease activated receptor 4 (PAR4) leads to release of urothelial macrophage migration inhibitory factor (MIF). MIF then binds to urothelial MIF receptors to release urothelial high mobility group box-1 (HMGB1) and ...
Shaojing Ye +8 more
doaj +1 more source
The comparative value of feline virology research: can findings from the feline lentiviral vaccine be translated to humans? [PDF]
, 2017 Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV).
Beczkowski, Paweł M. +5 more
core +1 more source
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5
Journal of Experimental Medicine, 1997 Infection with HIV-1 requires expression of CD4 and the chemokine receptors CXCR4 or CCR5 at the target cell surface. Engagement of these receptors by the HIV-1 envelope glycoprotein is essential for membrane fusion, but may additionally activate ...
C. Davis +8 more
semanticscholar +1 more source
Agonists for the Chemokine Receptor CXCR4
ACS Medicinal Chemistry Letters, 2011 The development of agonists for the chemokine receptor CXCR4 could provide promising therapeutic candidates. On the basis of previously forwarded two site model of chemokine-receptor interactions, we hypothesized that linking the agonistic N-terminus of SDF-1 to the T140 backbone would yield new high-affinity agonists of CXCR4.
Lefrançois, Marilou +8 more
openaire +2 more sources
RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
core +1 more source