Results 241 to 250 of about 371,200 (274)
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Journal of Clinical Immunology, 1990
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
Scott R. Presnell +3 more
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Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
Scott R. Presnell +3 more
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Current Opinion in Immunology, 1991
The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface.
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The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface.
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Cytokines and Their Receptors: An Overview
Therapeutic Drug Monitoring, 2000Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious candidates for exploitation as drugs or drug targets to promote, limit, or alter these responses in infection, allergy, autoimmunity, and other disease states.
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Cytokines and cytokine receptors in fetal growth and development
Biochemical Society Transactions, 2001The cytokine receptors for growth hormone (GH), prolactin and leptin have a critical role in regulating embryo, placental and/or fetal development, which is dependent on stage of gestation and species. GH and prolactin receptors are detectable from conception, and alterations in the maternal hormonal environment may impact on placental growth from this
Michael E. Symonds +2 more
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Cytokine Receptors of the Lung
American Journal of Respiratory Cell and Molecular Biology, 1991There has been a dramatic increase in studies on the potential role of cytokines in controlling the processes of inflammation, injury, and repair in the lung. A vast array or network has emerged including all of the cells that produce the various cytokines that have been identified and the target cells that respond to these mediators.
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Keratinocyte Cytokine and Chemokine Receptors [PDF]
Dermatologic Clinics, 2007 Chemokines are a superfamily of small, secreted proteins that regulate cell traffic in homeostatic and inflammatory conditions. Keratinocytes synthesize many chemokines, including members of the CC and CXC subfamilies, such as regulated on activation of normal T-cell expressed and secreted, gamma-interferon inducible protein-10, monokine induced by ...
Yalçın Tüzün +3 more
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Effects of cyclosporine on cytokines and cytokine receptors in psoriasis
Journal of the American Academy of Dermatology, 1995Oral cyclosporine is effective in the treatment of recalcitrant psoriasis. However, the precise mechanism(s) are not fully understood. A possible mode of action may be via down-modulation of proinflammatory cytokines that are increased in psoriatic lesions.This study was designed to monitor the effects of cyclosporine treatment on the expression of ...
Th. van Joost +5 more
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Nature, 1995
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Cytokine and cytokine receptor gene polymorphisms and their functionality
Cytokine & Growth Factor Reviews, 2009Cytokines, signaling proteins produced by a variety of cell types, are essential for the development and functioning of both innate and adaptive immune response. Cytokine gene expression is tightly regulated, and aberrant expression from environmental and genetic polymorphism has been implicated in a range of diseases, susceptibility to infections, and
Andrew J. Smith, Steve E. Humphries
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Rainbow trout cytokine and cytokine receptor genes
Immunological Reviews, 1998Summary: Transforming growth factor‐β (TGF‐β) and interleukin‐1β (IL‐1β) have been cloned from rainbow trout (Oncorhynchus mykiss) in our laboratory. The trout TGF‐β is typical of members of the cysteine knot cytokine family, and has highest homology to TGF‐β1, TGF‐β4 and TGF‐βs The gene organisation is different to other TGF‐β genes despite die ...
Christopher J. Secombes +5 more
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