Results 251 to 260 of about 371,200 (274)
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Cytokines, chemokines, and cytokine receptors in human microglia
Journal of Neuroscience Research, 2002AbstractEnriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type‐specific antigens for macrophage‐microglia lineage cells including CD11b (Mac‐1), CD68, B7‐2 (CD86), HLA‐ABC, HLA‐DR and ricinus communis aggulutinin lectin‐1 (RCA ...
Yong B. Lee +3 more
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Regulation of cytokine and cytokine receptor expression by glucocorticoids
Journal of Leukocyte Biology, 1996Abstract Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels. GCS were also reported to act indirectly by inducing transforming growth factor-β expression, which in turn blocks T cell immunity. In exerting their
Wassim Y. Almawi +3 more
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Cytokine Receptors: A New Superfamily of Receptors
1993Publisher Summary This chapter discusses the characteristics that define the structure and composition of the receptors and their ability to bind ligand and transduce signals, known as “signal transduction pathways,” and provides the evidence for oncogenic processes dependent on aberrant cytokine–receptor interactions.
Daniel M. Gorman +2 more
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Cytokine and cytokine receptor polymorphisms in infectious disease [PDF]
Intensive Care Medicine, 2000 Host immune responses strongly control the outcome of infectious disease, and the resistance to bacterial infections in humans is in part genetically determined. Responses to Gram-negative bacterial endotoxin are affected by the concentration of plasma lipoproteins and lipid transport proteins that are genetically controlled.
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Cytokine and cytokine receptor genes ‘captured’ by viruses
Current Opinion in Immunology, 1994Viruses have historically been used as tools to understand basic cellular functions. Recently viruses have been shown to encode genes whose protein products function to modulate the host immune system. Viral immune modulators can now be exploited for the purpose of further understanding cellular immune phenomena. These studies promise to provide a rich
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Inherited Cytokine and Cytokine Receptor Deficiencies in Man
International Reviews of Immunology, 1998Over the past decades, cytokines and their receptors have been shown to play a decisive role in the differentiation of both innate and adaptive immunity. The essential roles of cytokine/receptor pathways in vivo, however, have remained elusive and poorly defined.
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Cytokine Receptors and Signaling
2008Cytokines exert their effects after binding to specific cell surface receptors, which are composed of polypeptide chains. After the binding of the ligand to its receptor, there is an initiation of the signal transduction pathways culminating in the synthesis of new mRNA and protein synthesis, in most cases. Some of these pathways are unique targets for
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The Hematopoietic Cytokine Receptors
1996The growth and differentiation of hematopoietic stem cells to form the vast repertoire of mature blood cells that exists in vivo is orchestrated by an array of intercellular signals, mediated by cytokines in association with a complex stromal microenvironment.
Taisei Kinoshita +2 more
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Cytokines: Interleukins and Their Receptors
1995Preface R. Kurzrock, M. Talpaz. Receptors for Hematopoietic Regulatory Cytokines: Overview of Structure and Function U. Gullberg, et al. Control of Thrombocytopoiesis: Current State of the Art R. Hoffman, M.W. Long. Interleukin-I and its Inhibitors: Implications for Disease Biology and Therapy Z. Estrov, et al. Interleukin- 2: Its Rationale and Role in
Razelle Kurzrock, Moshe Talpaz
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Cytokines, Cytokine Receptors and Cytokine Antibodies: Clinical Implications
1997Cytokines are produced by almost any cell and function as important mediators of cell activation, differentiation and proliferation. These diffusibile glycoproteins appear to participate in the mediation of inflammatory as well as immune reactions, and some peptides may even influence tumor growth.
R. Caputo +3 more
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