Results 251 to 260 of about 611,331 (287)

Cytokines, receptors, and inhibitors

The Clinical Investigator, 1992
Cytokines are endogenous mediators in inflammatory and immunologic host defense reactions. In various diseases cytokines produced in excess cause systemic or local toxic effects. Cytokines therefore are tightly controlled by regulation of their biosynthesis and release and by counteracting mechanisms which limit their activities.
T. Braun, W. Lesslauer, G. Gehr
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Cytokines and their receptors

Current Opinion in Cell Biology, 1991
Cytokines act via receptor-mediated pathways to influence the regulation of both immune and non-immune cells. This review will discuss some of the most important developments over the past year which have contributed to the elucidation of the mechanisms of cell activation by these molecules.
openaire   +3 more sources

Cytokine Receptors and Their Ligands

2016
Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons and colony stimulating factors.
U. Dhagat, T.L. Nero, W.L. Kan, T.R. Hercus, S.E. Broughton, N.A. de Weerd, B.J. Jenkins, A. Mansell, M.A. Guthridge, P.J. Hertzog, A.F. Lopez, M.W. Parker   +11 more
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Cytokines and their receptor complexes

The FASEB Journal, 1995
The 3-dimensional structures that resulted from X-ray diffraction and nuclear magnetic resonance analyses of a variety of cytokines are reviewed. These proteins form distinct, well-defined superfamilies based on the structures of their monomers, even in the absence of significant sequence homology.
Alexander Wlodawer, David R. Davies
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Human cytokine receptors

Journal of Clinical Immunology, 1990
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
Scott R. Presnell, Zhi Chen, Wenfeng Xu, Wayne R. Kindsvogel   +3 more
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Cytokine receptors

Current Opinion in Immunology, 1991
The molecular characterization of cytokine receptors has progressed rapidly over the past 5 years as a result of availability of radiolabeled cytokines, as well as the identification or creation of cell lines that express significant numbers of receptors at the cell surface.
openaire   +2 more sources

Cytokines and Their Receptors: An Overview

Therapeutic Drug Monitoring, 2000
Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious candidates for exploitation as drugs or drug targets to promote, limit, or alter these responses in infection, allergy, autoimmunity, and other disease states.
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Cytokines and cytokine receptors in fetal growth and development

Biochemical Society Transactions, 2001
The cytokine receptors for growth hormone (GH), prolactin and leptin have a critical role in regulating embryo, placental and/or fetal development, which is dependent on stage of gestation and species. GH and prolactin receptors are detectable from conception, and alterations in the maternal hormonal environment may impact on placental growth from this
Michael E. Symonds, Alison Mostyn, Terence Stephenson   +2 more
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Cytokine Receptors of the Lung

American Journal of Respiratory Cell and Molecular Biology, 1991
There has been a dramatic increase in studies on the potential role of cytokines in controlling the processes of inflammation, injury, and repair in the lung. A vast array or network has emerged including all of the cells that produce the various cytokines that have been identified and the target cells that respond to these mediators.
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Effects of cyclosporine on cytokines and cytokine receptors in psoriasis

Journal of the American Academy of Dermatology, 1995
Oral cyclosporine is effective in the treatment of recalcitrant psoriasis. However, the precise mechanism(s) are not fully understood. A possible mode of action may be via down-modulation of proinflammatory cytokines that are increased in psoriatic lesions.This study was designed to monitor the effects of cyclosporine treatment on the expression of ...
Th. van Joost, R. Benner, O.E Ysselmuiden, Joost P.J.J. Hegmans, K 'tHooft-Benne, Errol P. Prens   +5 more
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