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2016
Cytokine receptors initiate intracellular signalling that regulate a diverse range of biological and medically important functions including metabolism control, neural stem cell activation, inflammatory responses, bone development, as well as blood cell and immune cell development and growth.
Brooks, Andrew J. +2 more
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Cytokine receptors initiate intracellular signalling that regulate a diverse range of biological and medically important functions including metabolism control, neural stem cell activation, inflammatory responses, bone development, as well as blood cell and immune cell development and growth.
Brooks, Andrew J. +2 more
openaire +2 more sources
The cytokine receptor superfamily
Blood Reviews, 1991The binding of haemopoietic growth factors and cytokines to specific receptors triggers a cascade of intracellular events which results in cell proliferation and differentiation. The knowledge of ligand-receptor-signal pathways is not only important in understanding the pathophysiology of malignant disease but also essential for devising future ...
R S, Kaczmarski, G J, Mufti
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Cytokines, receptors, and inhibitors
The Clinical Investigator, 1992Cytokines are endogenous mediators in inflammatory and immunologic host defense reactions. In various diseases cytokines produced in excess cause systemic or local toxic effects. Cytokines therefore are tightly controlled by regulation of their biosynthesis and release and by counteracting mechanisms which limit their activities.
G, Gehr, T, Braun, W, Lesslauer
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Cytokine receptor signaling pathways
Journal of Allergy and Clinical Immunology, 2000Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously.
W J, Leonard, J X, Lin
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Cytokine receptor signaling mechanisms
Current Opinion in Immunology, 1995Recent studies have dramatically advanced our understanding of the post-receptor signaling machinery engaged by members of the cytokine receptor superfamily. Proximal components of this signaling machinery are members of a novel class of protein tyrosine kinases termed JAKs. A working model proposes that ligand-induced dimerization of cytokine receptor
L M, Karnitz, R T, Abraham
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Current Opinion in Cell Biology, 1991
Cytokines act via receptor-mediated pathways to influence the regulation of both immune and non-immune cells. This review will discuss some of the most important developments over the past year which have contributed to the elucidation of the mechanisms of cell activation by these molecules.
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Cytokines act via receptor-mediated pathways to influence the regulation of both immune and non-immune cells. This review will discuss some of the most important developments over the past year which have contributed to the elucidation of the mechanisms of cell activation by these molecules.
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Cytokines, cytokine receptors and cytokine antibodies
Melanoma Research, 1996E. Berti, R. Caputo
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