Results 261 to 270 of about 611,331 (287)
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Nature, 1995
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Cytokine and cytokine receptor gene polymorphisms and their functionality
Cytokine & Growth Factor Reviews, 2009Cytokines, signaling proteins produced by a variety of cell types, are essential for the development and functioning of both innate and adaptive immune response. Cytokine gene expression is tightly regulated, and aberrant expression from environmental and genetic polymorphism has been implicated in a range of diseases, susceptibility to infections, and
Andrew J. Smith, Steve E. Humphries
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Rainbow trout cytokine and cytokine receptor genes
Immunological Reviews, 1998Summary: Transforming growth factor‐β (TGF‐β) and interleukin‐1β (IL‐1β) have been cloned from rainbow trout (Oncorhynchus mykiss) in our laboratory. The trout TGF‐β is typical of members of the cysteine knot cytokine family, and has highest homology to TGF‐β1, TGF‐β4 and TGF‐βs The gene organisation is different to other TGF‐β genes despite die ...
Christopher J. Secombes +5 more
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Cytokines, chemokines, and cytokine receptors in human microglia
Journal of Neuroscience Research, 2002AbstractEnriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type‐specific antigens for macrophage‐microglia lineage cells including CD11b (Mac‐1), CD68, B7‐2 (CD86), HLA‐ABC, HLA‐DR and ricinus communis aggulutinin lectin‐1 (RCA ...
Yong B. Lee +3 more
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Regulation of cytokine and cytokine receptor expression by glucocorticoids
Journal of Leukocyte Biology, 1996Abstract Glucocorticoids (GCS) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels. GCS were also reported to act indirectly by inducing transforming growth factor-β expression, which in turn blocks T cell immunity. In exerting their
Wassim Y. Almawi +3 more
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Cytokine Receptors: A New Superfamily of Receptors
1993Publisher Summary This chapter discusses the characteristics that define the structure and composition of the receptors and their ability to bind ligand and transduce signals, known as “signal transduction pathways,” and provides the evidence for oncogenic processes dependent on aberrant cytokine–receptor interactions.
Daniel M. Gorman +2 more
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Cytokine and cytokine receptor polymorphisms in infectious disease [PDF]
Intensive Care Medicine, 2000 Host immune responses strongly control the outcome of infectious disease, and the resistance to bacterial infections in humans is in part genetically determined. Responses to Gram-negative bacterial endotoxin are affected by the concentration of plasma lipoproteins and lipid transport proteins that are genetically controlled.
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Cannabinoid Receptors and the Cytokine Network [PDF]
, 1998 Splenocyte cultures from BALB/c mice were treated with THC and mitogen and shown to produce less Th1 cytokine, IFN gamma, and more Th2 cytokines, IL-4 and IL-10. This suggested that drug treatment caused a shift in the development of Th1 and Th2 cells. In studies designed to look at molecular mechanisms, the CBI antagonist, SR141716A, did not attenuate
Thomas W. Klein +2 more
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Cytokine and cytokine receptor genes ‘captured’ by viruses
Current Opinion in Immunology, 1994Viruses have historically been used as tools to understand basic cellular functions. Recently viruses have been shown to encode genes whose protein products function to modulate the host immune system. Viral immune modulators can now be exploited for the purpose of further understanding cellular immune phenomena. These studies promise to provide a rich
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Inherited Cytokine and Cytokine Receptor Deficiencies in Man
International Reviews of Immunology, 1998Over the past decades, cytokines and their receptors have been shown to play a decisive role in the differentiation of both innate and adaptive immunity. The essential roles of cytokine/receptor pathways in vivo, however, have remained elusive and poorly defined.
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