Results 41 to 50 of about 584,015 (163)
Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
doaj
Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors
Biosensors, 2020 Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19.
Eleonora Alfinito +2 more
doaj +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
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Cytokine production and signaling pathways in respiratory virus infection
Frontiers in Microbiology, 2013 It has been confirmed that respiratory virus infections can induce abberant cytokine production in the host. These cytokines may be associated with both elimination of the virus and complications in the host, such as virus-induced asthma.
Hirokazu eKimura +4 more
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Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics
Communications Biology, 2022 Peptides composed of two or more tandemly linked macrocyclic peptides binding to growth factor/cytokine receptors (STaMPtides) are useful growth factor/cytokine mimetics.
Kenichiro Ito +8 more
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Protein Palmitoylation in Leukocyte Signaling and Function
Frontiers in Cell and Developmental Biology, 2020 Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang +5 more
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Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors [PDF]
, 2014 Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune ...
Gow, Neil A R +9 more
core +3 more sources
Cytokines as cellular communicators
Mediators of Inflammation, 1996 Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse ...
R. Debets, H. F. J. Savelkoul
doaj +1 more source
F1000Research, 2018 Poxviruses encode a set of secreted proteins that bind cytokines and chemokines as a strategy to modulate host defense mechanisms. These viral proteins mimic the activity of host cytokine decoy receptors but have unique properties that may enhance their ...
Bruno Hernaez, Antonio Alcami
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Pro- and anti-inflammatory cytokines in threatened miscarriages [PDF]
, 2011 OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome.
Calleja-Agius, Jean +3 more
core +2 more sources