Results 41 to 50 of about 38,806 (274)

The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts

Frontiers in Molecular Neuroscience, 2019
The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system.
Nina Hahn, Luca Büschgens, Nicola Schwedhelm-Domeyer, Sarah Bank, Bart R. H. Geurten, Pia Neugebauer, Bita Massih, Martin C. Göpfert, Ralf Heinrich   +8 more
doaj   +1 more source

von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. [PDF]

PLoS Medicine, 2007
BACKGROUND: To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells from ...
Deric M Park, Zhengping Zhuang, Ling Chen, Nicholas Szerlip, Irina Maric, Jie Li, Taesung Sohn, Stephanie H Kim, Irina A Lubensky, Alexander O Vortmeyer, Griffin P Rodgers, Edward H Oldfield, Russell R Lonser   +12 more
doaj   +1 more source

Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

iScience
Summary: Erythropoietin-producing hepatoma (Eph) receptors, comprising the largest family of receptor tyrosine kinases (RTKs), exert profound influence on diverse biological processes and pathological conditions such as cancer.
Yuan Zhu, Sheng-an Su, Jian Shen, Hong Ma, Jixie Le, Yao Xie, Meixiang Xiang   +6 more
doaj   +1 more source

Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma [PDF]

Cancer, 2002
AbstractBACKGROUNDErythropoietin (Epo), induced by hypoxia, controls the survival, proliferation, and differentiation of Epo receptor (EpoR)‐bearing erythroid progenitors and plays a role in the protection of neurons from hypoxic damage. Hypoxia in malignant disease is associated with invasion, metastasis, resistance to therapy, and selection for cells
Geza, Acs, Paul J, Zhang, Timothy R, Rebbeck, Peter, Acs, Ajay, Verma   +4 more
openaire   +2 more sources

Association between high-dose erythropoiesis-stimulating agents, inflammatory biomarkers, and soluble erythropoietin receptors

BMC Nephrology, 2011
Background High-dose erythropoiesis-stimulating agents (ESA) for anemia of chronic kidney disease (CKD) have been associated with adverse clinical outcomes and do not always improve erythropoiesis.
Inrig Jula K, Bryskin Suzanne K, Patel Uptal D, Arcasoy Murat, Szczech Lynda A   +4 more
doaj   +1 more source

New horizons for newborn brain protection: enhancing endogenous neuroprotection. [PDF]

, 2015
Intrapartum-related events are the third leading cause of childhood mortality worldwide and result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult typically present with neonatal encephalopathy (NE).
Alonso-Alconada, D, Ezzati, M, Hassell, KJ, Hausenloy, DJ, Robertson, NJ   +4 more
core   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

Frontiers in Molecular Neuroscience, 2023
The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection.
Debbra Y. Knorr, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Ignacio Rodriguez Polo, Hanna S. Pies, Nicola Schwedhelm-Domeyer, Stephanie Pauls, Rüdiger Behr, Rüdiger Behr, Ralf Heinrich   +10 more
doaj   +1 more source

Structure of the Erythropoietin Receptor

Experimental Biology and Medicine, 1994
Despite extensive studies, the structure of the erythropoietin receptor remains little understood. cDNAs encoding the human and murine erythropoietin receptors have been cloned and the structure of these proteins is discussed. Although the proteins encoded by these cDNAs play key roles in erythropoietin binding and in erythropoietin signal transduction,
P, Mayeux, S, Pallu, S, Gobert, C, Lacombe, S, Gisselbrecht   +4 more
openaire   +2 more sources

Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin [PDF]

Blood, 1990
Abstract Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule.
A W, Wognum, P M, Lansdorp, R K, Humphries, G, Krystal   +3 more
openaire   +3 more sources