Results 111 to 120 of about 164,488 (314)

An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells

, 2010
The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells.
Charn, Tze Howe
core  

The role of estrogen receptor manipulation on persistent fear memory induced by traumatic stress exposure

, 2022
Knox, DayanPost traumatic stress disorder (PTSD) is a debilitating psychiatric disorder which stems from fear memory persistence after exposure to a traumatic experience. PTSD is associated with a high socioeconomic cost, as well as a higher prevalence
Biddle, Matthew
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Understanding the role of estrogen in the development of benign prostatic hyperplasia

African Journal of Urology, 2018
Introduction: Benign prostatic hyperplasia (BPH) is a non-malignant enlargement of the prostate that affects ageing men. As the number of men affected by this condition will only continue to grow with the aging population, finding new strategies and new ...
A. Ajayi, K. Abraham
doaj   +1 more source

Leptin receptor expression during the progression of endometrial carcinoma is correlated with estrogen and progesterone receptors

, 2016
Introduction : The hormone leptin, which is produced in the adipose tissue, may influence tumorigenesis directly via its receptor (Ob-R). Thus, a role for Ob-R in endometrial carcinogenesis has been proposed.
Luis Fernando Méndez-López, Ricardo M. Cerda-Flores, Angel Zavala-Pompa, Elva I. Cortés-Gutiérrez, Martha I. Davila-Rodriguez   +4 more
core   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Estrogen and Progesterone Receptors in the Endometrium

Annals of the New York Academy of Sciences, 1997
The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulation, for association with other ...
Moutsatsou, P., Sekeris, C.E.
openaire   +4 more sources

Alfa and beta estrogen receptors and the biliary tree

, 2002
This manuscript summarizes recent data showing that estrogens and their receptors play an important role in modulating cholangiocyte proliferation. We have recently demonstrated that rat cholangiocytes express both estrogen receptors (ER)-alpha and -beta
ALVARO, Domenico, S. S. Glaser, G. Alpini, FRANCHITTO, Antonio, F. Folli, G. Le Sage, ONORI, PAOLO, GAUDIO, EUGENIO, ATTILI, Adolfo Francesco   +8 more
core   +2 more sources

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus

Reproductive Biology and Endocrinology, 2009
Background In the mouse uterus, pregnancy is accompanied by changes in tachykinin and tachykinin receptor gene expression and in the uterotonic effects of endogenous tachykinins. In this study we have investigated whether changes in tachykinin expression
Patak Eva, Pennefather Jocelyn N, Pintado C Oscar, Pinto Francisco M, Candenas Luz   +4 more
doaj   +1 more source