Results 121 to 130 of about 164,488 (314)

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Andersson, AM, McLachlan, J, Steven F. Arnold, Arnold, SF, Philippe Grandjean, Andersen, HR, John P. Sumpter, Autrup, H, Henrik Leffers, Eva Bonefeld Jørgensen, Leffers, H, Ana M. Soto, Moller, A, Hummel, R, Oles-Karasko, A, Susan M. Thorpe, Beresford, NA, Perez, P, Thorpe, SM, Marianne Barfoed, Remy Le Guevel, Anette Møller, Nielsen, JB, Pakdel, F, Knud L. Pedersen, Pilar Perez, Christiansen, LB, Herman Autrup, Anita Oles-Karasko, Nicola A. Beresford, John McLachlan, Nicolas Olea, Skakkeboek, NE, Birgitte Gissel, Pedersen, KL, Korsgaard, B, Le Guevel, R, Grandjean, P, Lisette B. Christiansen, Bodil Korsgaard, Carlos Sonnenschein, Barfoed, M, Barfoed, N, Farzad Pakdel, René Hummel, Helle Raun Andersen, Gissel, B, Poul Bjerregaard, Bjerregaard, P, Soto, AM, Niels Erik Skakkebœk, Olea, N, Sumpter, JP, Anna-Maria Andersson, Jesper Bo Nielsen, Jorgensen, EB, Sonnenschein, C   +56 more
core   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Estrogenic Effects of the Extracts from the Chinese Yam (Dioscorea opposite Thunb.) and Its Effective Compounds in Vitro and in Vivo

Molecules, 2018
Background: The aim of this study was to explore the estrogenic effects of the extracts from Chinese yam and its effective compounds. Methods: The activity of the yam was investigated by the uterine weight gain of mice and a proliferation assay of breast
Mengnan Zeng, Li Zhang, Miao Li, Beibei Zhang, Ning Zhou, Yingying Ke, Weisheng Feng, Xiaoke Zheng   +7 more
doaj   +1 more source

Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family

, 2010
Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core  

Estrogen-Induced Apoptosis of Breast Epithelial Cells Is Blocked by NO/cGMP and Mediated by Extranuclear Estrogen Receptors

, 2010
Estrogen action, via both nuclear and extranuclear estrogen receptors (ERs), induces a variety of cellular signals that are prosurvival or proliferative, whereas nitric oxide (NO) can inhibit apoptosis via caspase S-nitrosylation and via activation of ...
Gregory R. J. Thatcher, Praneeth D. Edirisinghe, Praneeth D. Edirisinghe (194640), Gihani T. Wijewickrama (1926958), Irida Kastrati, Gregory R. J. Thatcher (7942685), Gihani T. Wijewickrama, Irida Kastrati (194639)   +7 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Mechanisms governing the protective effect of 17b-estradiol and estrogen receptors against cardiomyocyte injury

, 2012
[[abstract]]The sex hormone 17b-estradiol (E2) is the most abundant and active estrogen in premenopausal women. Studies have shown that high circulating levels of E2 are cardioprotective and are associated with reduced risk of developing heart disease in
黃志揚;HUANG, CHIH-YANG
core  

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Current Issues in Molecular Biology
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1).
Ju Rong, Xiaojun Xie, Yongdong Niu, Zhongjing Su   +3 more
doaj   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source