Results 231 to 240 of about 238,537 (264)

Fibroblast Growth Factors and Their Receptors in Parathyroid Disease

World Journal of Surgery, 1998
AbstractFibroblast growth factors (FGFs) comprise a family of polypeptide growth factors implicated in the control of proliferation of glandular tissues. The aim of this study was to determine whether FGFs are produced in normal and abnormal parathyroid glands and if these tissues have the potential to respond to this growth factor family.
Colby L. Eaton, Barnard J. Harrison, Darren Lambert   +2 more
openaire   +3 more sources

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Linda Jackson-Boeters, George P. Wysocki, Candice A Wakulich, Tom D. Daley   +3 more
openaire   +3 more sources

The Role of Fibroblast Growth Factor Receptors in Cancer

2021
Breast cancer accounts for a quarter of all cancers and ranks as the second most common cancer in the world. In particular, triple negative breast cancer is aggressive and lacks targeted therapeutic options. Hence, new therapeutic targets need to be identified for personalised treatment strategies to improve patient outcomes.
openaire   +2 more sources

Fibroblast Growth Factor and Epidermal Growth Factor Receptors in Ligament Healing

Clinical Orthopaedics and Related Research, 1997
Although recent in vivo studies indicate that basic fibroblast growth factor hastens the healing and strength of the medical collateral ligament after injury, in vitro studies with epidermal growth factor and basic fibroblast growth factor have shown increased fibroblast proliferation with the exogenous administration of these growth factors.
Stephen H. Liu, Gerald A. M. Finerman, Joseph M. Lane, Vah Panossian   +3 more
openaire   +3 more sources

Fibroblast Growth Factors and Their Receptors in Hematopoiesis and Hematological Tumors

Journal of Hematotherapy & Stem Cell Research, 2002
Fibroblast growth factors (FGFs) belong to a family of pleiotropic heparin-binding growth factors. They exert multiple functions on various cell types of mesodermal and neuroectodermal origin, affecting cell proliferation, motility, survival, and differentiation.
MORONI E., DELL'ERA, Patrizia, RUSNATI, Marco, PRESTA, Marco   +3 more
openaire   +4 more sources

Expression of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in the bovine corpus luteum

Molecular Reproduction and Development, 2007
AbstractThere is evidence that several fibroblast growth factors (FGFs) are involved in growth and development of the corpus luteum (CL), but many FGFs have not been investigated in this tissue, including FGF10. The objective of this study was to determine if FGF10 and its receptor (FGFR2B) are expressed in the CL.
Castilho, A. C., Giometti, I. C., Berisha, B., Schams, D., Price, C. A., Amorim, Renée Laufer, Papa, P. C., Buratini, J.   +7 more
openaire   +4 more sources

Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas

Journal of Neuro-Oncology, 1994
Malignant astrocytomas are highly invasive, vascular neoplasms that comprise the majority of nervous system tumors in humans. A strong association has previously been made between malignancy in human astrocytic tumors and increased expression of certain fibroblast growth factor (FGF) family members, including basic and acidic FGF.
Fumio Yamaguchi, Mitchel S. Berger, Richard S. Morrison, Hideyuki Saya, Janet M. Bruner, Lawrence A. Donehower, Alan M. Yahanda   +6 more
openaire   +3 more sources

Immunclocalization of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-1 and Receptor-2 in Rat Cranial Sutures

Plastic and Reconstructive Surgery, 1998
Craniosynostosis is a common disorder with an unknown etiology. Recent genetic mapping studies have demonstrated a strong linkage between several familial craniosynostotic syndromes and mutations in fibroblast growth factor receptor 1 (FGF-R1) and 2 (FGF-R2).
Michael T. Longaker, George K. Gittes, Babak J. Mehrara, Richard J. Mackool, Joseph G. McCarthy   +4 more
openaire   +3 more sources

Angiogenesis, Fibroblast Growth Factors, and Their Receptors

1999
The key determinants defining the earliest events in angiogenesis, vas-culogenesis, and the molecular differences that distinguish arteries from veins are now better understood than at any time to date. The adult vasculature consists of large arteries that progressively branch into smaller and smaller vessels terminating into precapillary arterioles ...
openaire   +2 more sources

Modulation of the epidermal growth factor receptor by basic fibroblast growth factor

Journal of Cellular Physiology, 1993
AbstractTreatment of Swiss 3T3 fibroblasts with basic fibroblast growth factor (bFGF) lead to a rapid reduction in epidermal growth factor (EGF) binding and a slower inhibition of EGF receptor autophosphorylation. The reduction in binding was due to a complete loss of the highest affinity EGF binding sites and a reduction in the lower affinity binding ...
openaire   +3 more sources