Results 231 to 240 of about 142,564 (264)

Anticancer molecules targeting fibroblast growth factor receptors

Trends in Pharmacological Sciences, 2012
The fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor tyrosine kinases: FGFR1-4. Upon ligand binding, FGFRs activate an array of downstream signaling pathways, such as the mitogen activated protein kinase (MAPK) and the phosphoinositide-3-kinase (PI3K)/Akt pathways.
Guang, Liang, Zhiguo, Liu, Jianzhang, Wu, Yuepiao, Cai, Xiaokun, Li   +4 more
openaire   +2 more sources

Immunohistochemical localization of growth factors fibroblast growth factor-1 and fibroblast growth factor-2 and receptors fibroblast growth factor receptor-2 and fibroblast growth factor receptor-3 in normal oral epithelium, epithelial dysplasias, and squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been identified in a variety of carcinomas, but there are few studies concerning their presence in oral cancers. The objective of this study was to determine whether FGF-1, FGF-2, and high affinity receptors FGFR2 and FGFR3 are present in the pathogenesis of oral epithelial dysplasias ...
Candice, Wakulich, Linda, Jackson-Boeters, Tom D, Daley, George P, Wysocki   +3 more
openaire   +2 more sources

Isoforms of Receptors of Fibroblast Growth Factors

Journal of Cellular Physiology, 2014
The breadth and scope of Fibroblast Growth Factor signaling is immense, with documentation of its role in almost every organism and system studied so far. FGF ligands signal through a family of four distinct tyrosine kinase receptors, the FGF receptors (FGFRs).
openaire   +2 more sources

Fibroblast Growth Factor and Epidermal Growth Factor Receptors in Ligament Healing

Clinical Orthopaedics and Related Research, 1997
Although recent in vivo studies indicate that basic fibroblast growth factor hastens the healing and strength of the medical collateral ligament after injury, in vitro studies with epidermal growth factor and basic fibroblast growth factor have shown increased fibroblast proliferation with the exogenous administration of these growth factors.
V, Panossian, S H, Liu, J M, Lane, G A, Finerman   +3 more
openaire   +2 more sources

Tumor targeting through fibroblast growth factor receptors

Seminars in Cancer Biology, 1995
Fibroblast growth factor tyrosine kinase receptors are encoded by four genes, but alternate splicing can result in more than 100 possible protein sequences. The receptors have widespread expression in the developing embryo, but the expression becomes more restricted in the adult.
openaire   +2 more sources

Fibroblast Growth Factor Receptor-Related Skeletal Disorders

2007
Four fibroblast growth receptor genes, FGFR1 to FGFR4, encode receptors for the 18 (or more) fibroblast growth factors. Any of the factors can bind to any of the receptors, although there are preferences. Structurally, the receptors consist of an extracellular region, comprising three immunoglobulinlike domains, a single hydrophobic segment that spans ...
openaire   +1 more source

Receptors for Fibroblast Growth Factors (FGFs)

1995
Abstract The different FGFR genes and their spliced variants are described in the literature under various names (Table 1). The five genes are now known as FGFR-1 (Lee et al. 1989), FGFR-2 (Dionne et al. 1990), FGFR-3 (Keegan et al. 1991), FGFR-4 (Partanen et al. 1991) and FGFR-5 (Avivi et al.
O Bernard, P Matthew
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Targeting Fibroblast Growth Factor/Fibroblast Growth Factor Receptor System in Angiogenesis

2007
RUSNATI, Marco, PRESTA, Marco
openaire   +3 more sources

Cancer treatment and survivorship statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Kimberly D Miller, Leticia M Nogueira, Angela B Mariotto   +2 more
exaly