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Functions of fibroblast growth factors and their receptors [PDF]
Current Biology, 1995 Fibroblast growth factors were first characterized twenty years ago as mitogens of cultured fibroblasts. Despite a wealth of data from experiments in vitro, insights have begun to emerge only recently on the normal function of these growth factors in mice and humans, as a result of studies of natural and experimental mutations in the factors and their ...
Wilkie, A +3 more
openaire +2 more sources
Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]
Veterinary World, 2016 Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval +4 more
doaj +1 more source
Cells, 2023 Cancer is the leading cause of death worldwide; thus, it is necessary to find successful strategies. Several growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF, FGF2), and transforming growth factor ...
Alessio Ardizzone +10 more
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Progress in Research on the Role of FGF in the Formation and Treatment of Corneal Neovascularization
Frontiers in Pharmacology, 2020 Corneal neovascularization (CNV) is a sight-threatening disease usually associated with inflammatory, infectious, degenerative, and traumatic disorders of the ocular surface.
Mengji Chen +4 more
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Presence and localization of a 30-kDa basic fibroblast growth factor-like protein in rodent testes [PDF]
, 1991 We have used a recently characterized rabbit antiserum against basic fibroblast growth factor (bFGF), which recognizes various forms of bFGF, to examine the presence and localization of bFGF in the testes of adult rats and mice and the 5-day-old rat.
Russell, J. T. +4 more
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Di-san junyi daxue xuebao, 2019 Objective To investigate the changes in the expression of fibroblast growth factor receptors 1-3 (FGFR1-3) at different stages of osteogenic differentiation and clarify the role of FGFR signaling in osteogenic differentiation.
MO Qifei, YANG Peng, SU Nan, CHEN Lin
doaj +1 more source
Analysis of Drosophila Fibroblast Growth Factor Functional Domains [PDF]
, 2011 The exciting Fibroblast Growth Factor (FGF) field lies at the crossroads of cell signaling, development, evolution, trafficking, physiology and human disease.
Tulin, Sarah Lynn
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The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]
Journal of Urologic OncologyDysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo +3 more
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Animals, 2021 The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo +10 more
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Functional dissection of the "Drosophila melanogaster" fibroblast growth factor signalling pathway in branching morphogenesis of the developing tracheal system [PDF]
, 2004 Fibroblast Growth Factor (FGF) signalling is involved in numerous developmental processes ranging from cell determination to mitogenesis, and cell survival to cell migration.
Dossenbach, Caroline
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