Results 51 to 60 of about 535,197 (344)
, 2009 Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania +40 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney [PDF]
Kidney International, 1999 Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney.The permanent kidney, or metanephros, develops through a complex series of reciprocal inductive events and involves branching morphogenesis, tubulogenesis, angiogenesis, and tissue remodeling. Fibroblast growth factors (FGFs) are
Cancilla, Belinda +2 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer
Cells, 2018 Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis.
Navid Sobhani +8 more
doaj +1 more source
Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors. [PDF]
Molecular and Cellular Biology, 1994 Ligand-induced dimerization and transphosphorylation are thought to be important events by which receptor tyrosine kinases generate cellular signals. We have investigated the ability of signalling-defective, truncated fibroblast growth factor (FGF) receptors (FGFR-1 and FGFR-2) to block the FGF response in cells that express both types of endogenous ...
Y, Li, C, Basilico, A, Mansukhani
openaire +2 more sources
Mathematical analysis of a model for the growth of the bovine corpus luteum [PDF]
, 2013 The corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy.
Mann, George +11 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
Apoptosis, 2013 The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair.
Kai Hung Tiong, L. Mah, C. Leong
semanticscholar +1 more source
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking [PDF]
, 2009 Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive.
Vladimir Berezin +16 more
core +1 more source