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Fibronectin and Its Receptors in Hematopoiesis [PDF]
Cells, 2020 Fibronectin is a ubiquitous extracellular matrix protein that is produced by many cell types in the bone marrow and distributed throughout it. Cells of the stem cell niche produce the various isoforms of this protein.
Franziska Wirth +3 more
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Integrin-specific signaling drives ER stress-dependent atherogenic endothelial activation [PDF]
Redox BiologyAtherogenic endothelial activation is driven by both the local arterial microenvironment, marked by altered extracellular matrix (ECM) composition and disturbed blood flow, and soluble proinflammatory cues such as oxidized low-density lipoprotein (oxLDL).
Cyrine Ben Dhaou +13 more
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Cells, 2022 The microenvironment of tumors is characterized by structural changes in the fibronectin matrix, which include increased deposition of the EDA isoform of fibronectin and the unfolding of the fibronectin Type III domains.
Anthony Ambesi +2 more
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Vietnam Journal of Science, Technology and Engineering, 2022 Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors.
Khon Huynh
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Frontiers in Medicine, 2022 Atherosclerosis is the major cause of cardiovascular disease that is characterized by plaque formation in the blood vessel wall. Atherosclerotic plaques represent sites of chronic inflammation with diverse cell content that is shifted toward the ...
Daria M. Potashnikova +9 more
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eLife, 2021 Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of ...
Jacopo Di Russo +5 more
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Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. [PDF]
PLoS ONE, 2015 Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth.
Patrick A Murphy +2 more
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Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. [PDF]
PLoS ONE, 2008 Fibronectin polymerization is essential for the development and repair of the extracellular matrix. Consequently, deciphering the mechanism of fibronectin fibril formation is of immense interest.
Elaine P S Gee +2 more
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Wnt5A modulates integrin expression in a receptor-dependent manner in ovarian cancer cells
Scientific Reports, 2021 Wnt5A signals through various receptors that confer versatile biological functions. Here, we used Wnt5A overexpressing human ovarian SKOV-3 and OVCAR-3 stable clones for assessing integrin expression, cell proliferation, migration, invasion, and the ...
Vajihe Azimian-Zavareh +5 more
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The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]
PLoS ONE, 2013 BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth +5 more
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