Results 21 to 30 of about 134,430 (166)

The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]

PLoS ONE, 2013
BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth, Jun Zhong, Celine Zumkeller, Chong Teck S'ng, Stephanie Goulet, Michael Tamm   +5 more
doaj   +1 more source

Enhanced Migratory Capacity of T Lymphocytes in Severe Chagasic Patients Is Correlated With VLA-4 and TNF-α Expression

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma cruzi infection in humans leads to progression to chronic chagasic myocarditis (CCM) in 30% of infected individuals, paralleling T cell inflammatory infiltrates in the heart tissue.
Luiz Ricardo Berbert, Florencia Belén González, Silvina Raquel Villar, Carlos Vigliano, Susana Lioi, Juan Beloscar, Oscar Adelmo Bottasso, Suse Dayse Silva-Barbosa, Wilson Savino, Wilson Savino, Wilson Savino, Ana Rosa Pérez   +11 more
doaj   +1 more source

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. [PDF]

, 1996
Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth.
Agrez, MV, Anseline, P, Bates, RC, Ferguson, N, Mitchell, D, Sheppard, D, Wilson, N   +6 more
core   +2 more sources

Synergistic growth factor microenvironments [PDF]

, 2016
Growth factors (GF) are remarkably powerful signalling molecules that orchestrate developmental biology. GFs are currently used in medjcal applications with limited success but it is clear that if their potential can be harnessed for biomedicine then ...
Dalby, Matthew J., Salmeron-Sanchez, Manuel   +1 more
core   +1 more source

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. [PDF]

PLoS ONE, 2013
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ.
Maryada Sharma, Anil Tiwari, Shweta Sharma, Preeti Bhoria, Vishali Gupta, Amod Gupta, Manni Luthra-Guptasarma   +6 more
doaj   +1 more source

Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway

Journal of Neuroinflammation, 2021
Background After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of
Shingo Yoshizaki, Tetsuya Tamaru, Masamitsu Hara, Ken Kijima, Masatake Tanaka, Dai-jiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada   +8 more
doaj   +1 more source

Molecular Docking Characterization of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop with Hydroxyapatite

Molecules, 2013
Fibronectin adsorption on biomaterial surfaces plays a key role in the biocompatibility of biomedical implants. In the current study, the adsorption behavior of the 7–10th type III modules of fibronectin (FN-III7–10) in the presence of hydroxyapatite ...
Tailin Guo, Wenyuan Kang, Dongqin Xiao, Rongquan Duan, Wei Zhi, Jie Weng   +5 more
doaj   +1 more source

HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway

Skeletal Muscle, 2017
Background The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle ...
Mariela Natacha González, Wallace de Mello, Gillian S. Butler-Browne, Suse Dayse Silva-Barbosa, Vincent Mouly, Wilson Savino, Ingo Riederer   +6 more
doaj   +1 more source

Inhibitors of Human Neuraminidase Enzymes Block Transmigration in vitro

Frontiers in Molecular Biosciences, 2022
Cell migration to a site of inflammation is an important step of the immune response. This process is coordinated by cytokines, receptors, and the signal processing machinery of the cell.
Md. Amran Howlader, Tianlin Guo, Christopher W. Cairo   +2 more
doaj   +1 more source

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]

, 2016
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C, Bickle, M, Carthy, JM, Gahman, TC, Heldin, A, Heldin, CH, Kardassis, D, Morén, A, Moustakas, A, Shiau, AK, Stöter, M, Vanlandewijck, M, Zerial, M   +12 more
core   +1 more source