Results 31 to 40 of about 134,430 (166)

Short Hairpin RNA-Mediated Fibronectin Knockdown Delays Tumor Growth in a Mouse Glioma Model

Neoplasia: An International Journal for Oncology Research, 2010
Glioblastoma multiforme is the most common and lethal primary brain tumor. Glioma progression depends on the rapid proliferation of tumor cells accompanied by an acute immunosuppressive environment, facilitated mainly by tumor infiltration of regulatory ...
Sadhak Sengupta, Suvobroto Nandi, Enal S. Hindi, Derek A. Wainwright, Yu Han, Maciej S. Lesniak   +5 more
doaj   +1 more source

Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism

Neoplasia: An International Journal for Oncology Research, 2014
Inhibitors of the mammalian target of rapamycin (mTOR) have improved the treatment of renal cell carcinoma (RCC). However, chronic drug exposure may trigger resistance, limiting the utility of these agents.
Eva Juengel, Jasmina Makarević, Michael Reiter, Jens Mani, Igor Tsaur, Georg Bartsch, Axel Haferkamp, Roman A. Blaheta   +7 more
doaj   +1 more source

Evaluation of Renoprotective Effect of Lipoic Acid and Bosentan Against Diclofenac-Induced Acute Renal Failure

Iraqi Journal of Pharmaceutical Sciences, 2023
Acute renal failure also known as acute kidney injury (AKI) is a complex health condition related to significant morbidity and mortality. In hospitalized patients, around 19-33 percent of AKI episodes are linked to drug induced nephrotoxicity.
Lina Al-Hasani, Ghaith A. Jasim, Ihsan S. Rabeea   +2 more
doaj   +1 more source

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation [PDF]

, 2019
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different cellular models, even though no ...
Díaz, Emilce Silvina, Kong, Milene, Martínez León, Eduardo Antonio, Morales, Patricio, Osycka Salut, Claudia Elena, Perez Martinez, Silvina Laura, Signorelli, Janetti   +6 more
core   +1 more source

Mechanotransduction and growth factor signalling to engineer cellular microenvironments [PDF]

, 2017
Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells.
Anderson, Arnold, Azevedo, Baker, Balaban, Banks, Bathawab, Belair, Bidan, Bissell, Briquez, Burdick, Caliari, Cantini, Cantini, Cavalcanti-Adam, Chang, Chaudhuri, Chaudhuri, Chen, Chen, Cipitria, Cipitria, Cipitria, Comoglio, Cosgrove, Crouzier, Crouzier, Cuatrecasas, Curran, Curtis, Dalby, Dalby, Davis, DeForest, Delplace, Discher, Ehrlich, Ellison, Engler, Engler, Fan, Flemming, Geiger, Gilde, Gjorevski, Gonzalez-Garcia, Gugutkov, Guvendiren, Guvendiren, Hanjaya-Putra, Huang, Huebsch, Huebsch, Hutmacher, Hynes, Ingber, Ingber, Ito, Ito, Khetan, Kilian, Kim, Kim, Kim, Kleinman, Kloxin, Kloxin, Kocer, Kong, Kuhl, Kustra, Lee, Lee, Liu, Llopis-Hernandez, Llopis-Hernandez, Lo, Lu, Lutolf, Mabry, Mammoto, Maniotis, Mantovani, Mao, Marklein, Martino, Martino, Martino, Martino, McBeath, McMurray, Mitchell, Moore, Morrison, Moulisova, Nelson, Nelson, Newcomb, Oh, Pankov, Park, Pelham, Reichert, Rice, Rico, Roca-Cusachs, Ruiz, Rumpler, Sacchi, Salmeron-Sanchez, Salmeron-Sanchez, Schultz, Schwab, Schwarzbauer, Seo, Seo, Silva, Sochol, Straley, Sunyer, Tan, Tan, Tibbitt, Tong, Trappmann, Vincent, Vogel, Wang, Wang, Wang, Wen, Wijelath, Woo, Yang, Yeung, Young, Yu, Yu, Zhang, Zouani   +140 more
core   +1 more source

Levels of isoforms of fibronectin and α5/CD49e integrin on lymphocytes and in blood plasma in the conditions of chronic diffuse liver diseases

Regulatory Mechanisms in Biosystems, 2020
Chronic diffuse liver diseases are characterized by accumulation of complex inflammatory infiltrate in the liver tissues, blood, and lympha, and activation of the immune system.
H. V. Dolhikh, H. S. Maslak, V. I. Didenko, I. A. Klenina, А. О. Dolhikh   +4 more
doaj   +1 more source

Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC). [PDF]

PLoS ONE, 2017
The connective tissue formed by extracellular matrix (ECM) rich in fibronectin and collagen consists a barrier that cancer cells have to overpass to reach blood vessels and then a metastatic site. Cell adhesion to fibronectin is mediated by αvβ3 and α5β1
Cyntia F Montenegro, Bruna C Casali, Rafael L B Lino, Bianca C Pachane, Patty K Santos, Alan R Horwitz, Heloisa S Selistre-de-Araujo, Marcelo L Lamers   +7 more
doaj   +1 more source

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. [PDF]

, 2003
A considerable body of research indicates that mammary gland branching morphogenesis is dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and other ECM receptors, and ECM-degrading enzymes, including matrix ...
A Amour, A Garcia-Gasca, A Lochter, A Lochter, AC Andres, AJ D'Ardenne, AM Belkin, AR Nelson, B Lelongt, BL Hogan, BM Gumbiner, BS Wiseman, C Brisken, C Brisken, CJ Sympson, CS Atwood, CW Daniel, CW Daniel, D Alford, D Alford, DG Stupack, ED Hay, EW Thompson, F Berdichevsky, F Kheradmand, FE Jones, G Bani, G Giannelli, G Shyamala, GB Silberstein, GB Silberstein, GB Silberstein, GB Silberstein, GL Ganser, GW Robinson, GW Robinson, GW Robinson, H Birkedal-Hansen, H Joseph, HJ Hathaway, HY Ha, J Chen, J Lilla, J Muschler, J Russo, J Schlondorff, J Yant, JE Fata, JE Fata, JE Fata, JE Ferguson, JF Wiesen, JJ Wysolmerski, JJ Wysolmerski, JM Bradbury, JM Whitelock, JM Williams, JP Irigoyen, JP Lydon, JP Witty, JT Emerman, K Elenius, K Hotary, K Ito, K Morita, K Wolf, L Hennighausen, LA Rudolph-Owen, LA Rudolph-Owen, LJ van't Veer, LR Lund, M Affolter, M Durbeej, M Egeblad, M Rytomaa, M Simian, MA Arnaout, MD Infeld, MD Sternlicht, MF Horster, MH Barcellos-Hoff, MJ van de Vijver, MM Zutter, MM Zutter, MP Osborne, MR Crowley, MR Warner, MS Wicha, N Koshikawa, N Quarto, NJ Kenney, NK Wessells, OW Petersen, P Bashkin, PR Warfield, PY Desprez, R Lagace, RH Wetzels, RS Talhouk, S Coleman, S Mukherjee, S Selvarajan, S Sinha, S Stahl, SD Banerjee, SD Robinson, SE Baker, SH Barsky, SL Bullock, SM Ellerbroek, T Darribere, T Gudjonsson, T Hayakawa, T Hayakawa, T Hayakawa, TC Klinowska, TC Klinowska, TC Klinowska, TH Vu, TN Seagroves, U Felbor, V Gouon-Evans, V Noe, VM Weaver, W Ruan, W Wang, W Xie, WF Vogel, WF Vogel, WH Yu, WP Bocchinfuso, Y Fukuda, Y Fukuda, Y Hirai, Y Hirai, Y Kadono, Y Nakanishi, YS Kanwar, Z Werb, Z Zhu   +139 more
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Fibronectin in human gallbladder bile: cholesterol pronucleating and/or mucin "link" protein? [PDF]

, 1994
Some biliary proteins (pronucleators) seem to be essential factors for cholesterol crystal formation and crystal growth in bile. A recent study suggests that fibronectin is such a pronucleator in bile.
Del Pozo, Reginals, Jüngst, Dieter, Lange, Volker, Miquel, Juan Francisco, Paumgartner, Gustav, Ritter, Christoph von   +5 more
core   +1 more source

Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells.

PLoS ONE, 2015
Therapeutic angiogenesis may be applied in medical conditions to promote stimulation of angiogenesis. Angiogenesis is a multistep process, which includes endothelial cell proliferation, migration, and tube formation, which is mediated by various ...
Iana Mayane Mendes Nicácio Viana, Maíra Estanislau Soares de Almeida, Marvin Paulo Lins, Maria Danielma dos Santos Reis, Larissa Fernanda de Araújo Vieira, Salete Smaniotto   +5 more
doaj   +1 more source