Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. [PDF]
PLoS ONE, 2014 Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
Irene Gallo +7 more
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Formyl peptide receptors in the mucosal immune system [PDF]
Experimental and Molecular Medicine, 2020 Formyl peptide receptors: Receptors in the mucosal immune system Key receptors in defense against bacteria may also be attractive targets for diseases of the mucosa, the tissue that lines and protects areas such as the airways and gastrointestinal tract.
Yu Sun Jeong, Yoe-Sik Bae
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Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases [PDF]
MoleculesIn physiological situations involving cell damage, molecules derived from mitochondria or bacteria are produced. These molecules are known as N-formyl peptides and are detected by formyl peptide receptors (FPRs), which stimulate immune cells to migrate ...
Livia Alvarenga +5 more
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Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Life, 2022 Formyl peptide receptors, abbreviated as FPRs in humans, are G-protein coupled receptors (GPCRs) mainly found in mammalian leukocytes. However, they are also expressed in cell types crucial for homeostatic brain regulation, including microglia and blood ...
Edward S. Wickstead +2 more
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Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene [PDF]
Advanced ScienceChanges in the composition of specific cell‐surface molecules on immune cells are important early markers of directed immune responses. Current biosensors largely focus on detecting soluble disease markers.
Ahmar Hasnain +5 more
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The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease [PDF]
Frontiers in ImmunologyPattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells and play a crucial role in the proper function of the innate immune system.
Filomena Napolitano +2 more
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Assessing the potential of bacterial signal peptides for radiopharmaceutical applications [PDF]
Scientific ReportsBacterial signal peptides are a large group of high-affinity ligands for formyl peptide receptors (FPRs). These receptors are highly enriched on the surface of glioblastomas and several other tumor types.
Zukaa Al Taleb +5 more
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Fragments of viral surface proteins modulate innate immune responses via formyl peptide receptors [PDF]
iScienceSummary: Formyl peptide receptors (FPRs) are pattern recognition receptors well-known for bacterial pathogen sensing. We here identified activator and inhibitor motifs for FPRs that are present on surface proteins of various viral pathogens.
Heiko Heilmann +7 more
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Frontiers in Immunology, 2021 Non-responsiveness to anti-TNF-α therapies presents relevant rates in inflammatory bowel disease patients, presenting the need to find biomarkers involved in therapeutic efficacy.
Marina de Paula-Silva +10 more
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NEW FORMYL PEPTIDE HAS THE STIMULATING PROPERTIES IN POINT OF IMMUNE SYSTEM CELLS [PDF]
Annals of Mechnikov's Institute, 2017 Introduction Tuberculosis infection (TBI) is still one of the major health problems, despite of global intensive medical and pharmaceutical efforts as it is known, in the majority of immunocompetent individuals TBI is repressed by immune system, and as a
Martynov A. V. +6 more
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