Results 11 to 20 of about 18,956 (224)

FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. [PDF]

PLoS ONE, 2016
In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and induce a systemic inflammatory response syndrome similar to that observed during septic shock.
Cristina Ionica Øie, Igor Snapkov, Kjetil Elvevold, Baldur Sveinbjørnsson, Bård Smedsrød   +4 more
doaj   +1 more source

New Insights on Formyl Peptide Receptor Type 2 Involvement in Nociceptive Processes in the Spinal Cord

Life, 2022
Formyl peptide receptor type 2 (FPR2/ALX) belongs to the formyl peptide receptors (FPRs) family clustered on chromosome 19 and encodes a family of three Class A of G protein-coupled receptors (GPCRs).
Mariantonella Colucci, Azzurra Stefanucci, Adriano Mollica, Anna Maria Aloisi, Francesco Maione, Stefano Pieretti   +5 more
doaj   +1 more source

Formyl peptide receptor 2 and heart disease

Seminars in Immunology, 2022
Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease, dysregulated inflammation can potentiate maladaptive healing and pathological remodeling of the heart leading to cardiac dysfunction and failure.
John A, Lupisella, Pravin S, Shirude, Nicholas R, Wurtz, Ricardo A, Garcia   +3 more
openaire   +2 more sources

Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice

Membranes, 2023
The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood.
Irina Tikhonova, Alsu Dyukina, Elvira Shaykhutdinova, Valentina Safronova   +3 more
doaj   +1 more source

FPR1 (formyl peptide receptor 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on FPR1 (formyl peptide receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Huang, J, Wang, JM
openaire   +2 more sources

Expression and function of receptors for the formylated peptides in granulocytes of the patients with rheumatoid arthritis

Медицинская иммунология, 2022
Formyl peptide receptors (FPRs) are an important part of innate immunity involved in antimicrobial phagocyte functions such as chemotaxis, secretory degranulation, and respiratory burst.
A. Mohammad, Yu. V. Filina, R. V. Larionova, M. I. Arleevskaya, A. G. Gabdulhakova   +4 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Structural basis of ligand binding modes at the human formyl peptide receptor 2

Nature Communications, 2020
Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex with
Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu, Qiang Zhao, Beili Wu   +12 more
doaj   +1 more source

The Role of Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation

Frontiers in Cellular Neuroscience, 2021
Formyl peptide receptors (FPRs) are a group of G protein-coupled cell surface receptors that play important roles in host defense and inflammation. Owing to the ubiquitous expression of FPRs throughout different cell types and since they interact with ...
Jiahui Zhu, Lingfei Li, Jiao Ding, Jinyu Huang, Anwen Shao, Bo Tang   +5 more
doaj   +1 more source

The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity

Journal of Innate Immunity, 2021
Neutrophils express the two formyl peptide receptors (FPR1 and FPR2) and the medium-chain fatty acid receptor GPR84. The FPRs are known to define a hierarchy among neutrophil G protein-coupled receptors (GPCRs), that is, the activated FPRs can either ...
Jonas Mårtensson, Martina Sundqvist, Asmita Manandhar, Loukas Ieremias, Linjie Zhang, Trond Ulven, Xin Xie, Lena Björkman, Huamei Forsman   +8 more
doaj   +1 more source