Results 271 to 280 of about 162,039 (295)
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2007
γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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GABA-receptors in peripheral tissues
Life Sciences, 1990Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
Jennifer Ong, David I.B. Kerr
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GABA-B Receptors in Drosophila
2010Drosophila melanogaster, the "fruit fly," is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively
Svetlana Dzitoyeva, Hari Manev
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Nonsynaptic Receptors for GABA and Glutamate
Current Topics in Medicinal Chemistry, 2006The concept of nonsynaptic communication between neurons, once a heretic idea, has become a self-evident fact during the almost forty years since its original discovery. In this review we investigate whether the archetypical synaptic transmitters of the central nervous system, Glu and GABA, can operate via nonsynaptic transmission.
Arpad Mike, E.S. Vizi
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Bicuculline and Central GABA Receptors
Nature, 1970WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
David R. Curtis +3 more
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GABA Receptors and Phospholipids
1978The sodium-independent binding of GABA to certain membrane preparations from rat brain exhibits many of the properties of the interaction of GABA with postsynaptic receptors anticipated from in vivo studies (see papers by Enna and Olsen, this meeting).
S. M. E. Kennedy, Graham A.R. Johnston
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GABA and Its Receptors in Epilepsy
2004Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain. It acts through 2 classes of receptors, GABAA receptors that are ligand-operated ion channels and the G-protein-coupled metabotropic GABAB receptors. Impairment of GABAergic transmission by genetic mutations or application of GABA receptor antagonists ...
Susanne Pirker +3 more
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Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Sergej Kolbaev +2 more
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Benzodiazepine interactions with GABA receptors
Neuroscience Letters, 1984Benzodiazepines (BZs) produce most, if not all, of their pharmacological actions by specifically enhancing the effects of endogenous and exogenous GABA that are mediated by GABAA receptors. This potentiation consists in an increase of the apparent affinity of GABA for increasing chloride conductance without increase in its efficacy and, on the single ...
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2014
Glutamate and GABA receptors are amino acid neurotransmitters present in the central nervous system. They are involved with nociception at multiple levels. Glutamate causes excitation and GABA causes inhibition.
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Glutamate and GABA receptors are amino acid neurotransmitters present in the central nervous system. They are involved with nociception at multiple levels. Glutamate causes excitation and GABA causes inhibition.
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