Results 11 to 20 of about 2,748,395 (254)
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice
Molecular Metabolism, 2022 Objective Pharmacological strategies that engage multiple mechanisms-of-action have demonstrated synergistic benefits for metabolic disease in preclinical models.
P. Knerr +10 more
semanticscholar +1 more source
Glucagon Receptor Signaling and Glucagon Resistance [PDF]
International Journal of Molecular Sciences, 2019 Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas).
Lina Janah +8 more
openaire +4 more sources
Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. [PDF]
PLoS ONE, 2015 This study evaluated the chronotropic and inotropic responses to glucagon in spontaneously beating isolated right atria of rat heart. For comparison, we also investigated the effects resulting from stimulating β-adrenoceptors with isoproterenol in this ...
Beatriz Merino +2 more
doaj +1 more source
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice [PDF]
Molecular Metabolism, 2022 Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice.Chronic effects of glucagon receptor signaling on lipid metabolism were studied using oral lipid tolerance tests (OLTTs) in ...
Galsgaard, Katrine D. +16 more
openaire +4 more sources
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon. [PDF]
PLoS ONE, 2016 GLP-1 and glucagon regulate glucose metabolism through a network of metabolic pathways initiated upon binding to their specific receptors that belong to class B G-protein coupled receptors (GPCRs). The therapeutic potential of glucagon is currently being
Deena A Oren +5 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the ...
Ying Wang +9 more
doaj +1 more source
Altered cannabinoid receptor expression in pancreatic islets in experimental model of uraemia
Folia Morphologica, 2020 BACKGROUND: Uraemia leads to a number of metabolic and hormonal disorders including defective carbohydrate metabolism. Endocannabinoids exert their effect on insulin and glucagon secretion via activation of specific receptors named CB1 and CB2.
P. Nowińska +3 more
doaj +1 more source
The incretin/glucagon system as a target for pharmacotherapy of obesity
Obesity Reviews, 2021 Obesity is a chronic, multifactorial, relapsing disease. Despite multicomponent lifestyle interventions, including pharmacotherapy, maintaining bodyweight loss is challenging for many people.
S. Del Prato +3 more
semanticscholar +1 more source
The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery
Frontiers in Genetics, 2021 Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
Daria Skuratovskaia +7 more
doaj +1 more source
Nature Communications, 2022 Glucagon-like peptide-1 receptor (GLP1R) agonists are used to treat type 2 diabetes (T2D), and polyagonists targeting multiple hormone receptors are investigated as potential therapeutics for T2D.
Hongwei Jiang +12 more
doaj +1 more source