Results 21 to 30 of about 2,748,395 (254)

Histologic distribution of insulin and glucagon receptors

Brazilian Journal of Medical and Biological Research, 1998
Insulin and glucagon are the hormonal polypeptides secreted by the B and A cells of the endocrine pancreas, respectively. Their major physiologic effects are regulation of carbohydrate metabolism, but they have opposite effects. Insulin and glucagon have
M. Watanabe, H. Hayasaki, T. Tamayama, M. Shimada   +3 more
doaj   +1 more source

Variation in responses to incretin therapy: Modifiable and non-modifiable factors

Frontiers in Molecular Biosciences, 2023
Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss.
Gregory O. Austin, Alejandra Tomas
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source

Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

iScience, 2023
Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is ...
Huixia Wang, Wanhui Hu, Tiandan Xu, Ya Yuan, Dongsheng Liu, Kurt Wüthrich   +5 more
doaj   +1 more source

Treatment of type 2 diabetes by free fatty acid receptor agonists [PDF]

, 2014
Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors.
Hudson, Brian D., Milligan, Graeme, Ulven, Trond, Watterson, Kenneth R.   +3 more
core   +2 more sources

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

Pharmacological Reviews, 2016
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class B G protein–coupled receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three major tissues in humans, enteroendocrine L cells in the distal intestine, α cells ...
C. de Graaf, D. Donnelly, D. Wootten, J. Lau, P. Sexton, L. Miller, Jung-Mo Ahn, Jia-yu Liao, Madeleine M. Fletcher, Dehua Yang, Alastair J. H. Brown, Cai-hong Zhou, Jiejie Deng, Ming-Wei Wang   +13 more
semanticscholar   +1 more source

Hepatic glucagon receptors expression in response to glucose, insulin, glucagon and immune challenge in grass carp (Ctenophcuyngodon idellus)

Aquaculture Reports, 2020
Since discovery, glucagon biology has remained enigmatic. Studies have shown that glucagon may have physiological effects beyond glucose regulation by binding to its receptor (Gcgr).
Chaobin Qin, Wenli Zhao, Guokun Yang, Hui Cao, Liping Yang, Xiaolin Meng, Xiao Yan, Guoxing Nie   +7 more
doaj   +1 more source

Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration [PDF]

, 1994
Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size).
Carr, BI, Francavilla, A, Polimeno, L, Porter, KA, Starzl, TE, Sun, D, van Thiel, DH, Zeng, Q   +7 more
core   +1 more source