Results 1 to 10 of about 151,397 (309)

The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application [PDF]

Biomedicines
Steroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid
Yao Wang, Ying Zhou, Yao Yao, Caihong Zheng   +3 more
doaj   +2 more sources

Conditioned medium from human tonsil-derived mesenchymal stem cells inhibits glucocorticoid-induced adipocyte differentiation.

PLoS ONE, 2022
Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu   +4 more
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Irisin regulates the phosphorylation of glucocorticoid receptor Ser212 and Ser234 and mediates glucocorticoid-induced muscle atrophy in mice [PDF]

Communications Biology
Glucocorticoid-induced skeletal muscle atrophy severely limits the clinical use of glucocorticoids and occurs in various endocrine and metabolic diseases.
Jingjing Yang, Pu Zhang, Yina An, Shuyu Tan, Siqi Sun, Yifan Liu, Lin Zhu, Haidong Wang, Ting Gao, Yanjun Dong   +9 more
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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity

Neurobiology of Stress, 2023
Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett, Guia Guffanti, Richard G. Hunter   +2 more
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Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder

Frontiers in Psychiatry, 2022
IntroductionAbnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients ...
José Manuel López-Villatoro, Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Marina Diaz-Marsá, Marina Diaz-Marsá, Alejandro De La Torre-Luque, Alejandro De La Torre-Luque, Clara Prittwitz, Alejandra Galvez-Merlin, Juan C. Leza, Juan C. Leza, Juan C. Leza, Juan C. Leza, Jose L. Carrasco, Jose L. Carrasco   +16 more
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Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

PLoS ONE, 2020
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone
John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman   +9 more
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Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Nature Communications, 2021
Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul   +13 more
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Regulation of the kiss2 promoter in yellowtail clownfish (Amphiprion clarkii) by cortisol via GRE-dependent GR pathway

Frontiers in Endocrinology, 2022
Kisspeptin plays a vital role in mediating the stress-induced reproductive regulation. Cortisol, known as a stress-related hormone, is involved in gonadal development and sexual differentiation by binding with glucocorticoid receptor (GR) to regulate the
Shao-Yang Bu, Yan-Yu Zhang, Xian Zhang, Tian-Xiu Li, De-Cai Zheng, Ze-Xiang Huang, Qian Wang   +6 more
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Hippocampal glucocorticoid receptors modulate status epilepticus severity

Neurobiology of Disease, 2023
Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population ...
Kimberly L. Kraus, Nawshaba Nawreen, Christin M. Godale, Arihant P. Chordia, Ben Packard, Candi L. LaSarge, James P. Herman, Steve C. Danzer   +7 more
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Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain

Neurobiology of Stress, 2023
Hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) mediate glucocorticoid hormone (GC) action in the hippocampus.
Clare L.M. Kennedy, Emily M. Price, Karen R. Mifsud, Silvia Salatino, Eshita Sharma, Simon Engledow, John Broxholme, Hannah M. Goss, Johannes M.H.M. Reul   +8 more
doaj   +1 more source