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The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application [PDF]
BiomedicinesSteroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid
Yao Wang +3 more
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Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague–Dawley rats [PDF]
Physiological ReportsIn the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress ...
D. Sztechman +4 more
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Glucocorticoid receptors modulate mitochondrial function
Communicative & Integrative Biology, 2009 It has become increasingly clear that glucocorticoid (GC) signaling not only comprises classic nuclear receptor binding—that is, glucocorticoid receptors (GRs) to their response element in the nucleus—but also involves rapid, non-genomic efforts to ...
Jing Du, Bruce McEwen, Husseini K. Manji
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Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis
Cells, 2023 The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG).
Pinkal D. Patel +2 more
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Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Nature, 2021 Chunyou Mao, Peng Xiao, Yi Jiang
exaly +2 more sources
PLoS ONE, 2022 Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim +4 more
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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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Frontiers in Psychiatry, 2022 IntroductionAbnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients ...
José Manuel López-Villatoro +16 more
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Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
Nature Communications, 2021 Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud +13 more
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