Results 1 to 10 of about 2,325,908 (46)
Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective
Journal of the Endocrine Society, 2019 Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)—members of the family of nuclear receptors. MRs and GRs can mediate
Anne M. Koning +3 more
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Science Signaling, 2019 Skewing glucocorticoid signaling to favor mineralocorticoid receptor activation is detrimental to the heart. A balancing act for the heart Stress increases the risk of dying from cardiometabolic disease.
R. Oakley +9 more
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Endocrinology, 2019 Mineralocorticoid and glucocorticoid receptors (MRs and GRs) constitute a functionally important dual receptor system detecting and transmitting circulating corticosteroid signals.
C. Rivers +5 more
semanticscholar +1 more source
Glucocorticoid receptors: finding the middle ground.
Journal of Clinical Investigation, 2017 Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with potent anti-inflammatory and immune modulatory profiles. Depending on the context, these hormones can also mediate pro-inflammatory activities, thereby serving as ...
Sofie J. Desmet, K. De Bosscher
semanticscholar +1 more source
Comparing the rules of engagement of androgen and glucocorticoid receptors
Cellular and Molecular Life Sciences, 2017 Despite the diverse physiological activities of androgens and glucocorticoids, the corresponding receptors are very close members of the nuclear-receptor super family.
F. Claessens, S. Joniau, C. Helsen
semanticscholar +1 more source
Cellular and Molecular Life Sciences, 2014 Adult neurogenesis, the birth of new neurons in the mature brain, has attracted considerable attention in the last decade. One of the earliest identified and most profound factors that affect adult neurogenesis both positively and negatively is stress ...
D. Saaltink, E. Vreugdenhil
semanticscholar +1 more source
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
Stress, 2018 The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted from the adrenal gland in response to stress.
Julia K Gjerstad, S. Lightman, F. Spiga
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Critical Care, 2013 BackgroundA protective role for glucocorticoid therapy in animal models of sepsis was shown many decades ago. In human sepsis, there is new interest in glucocorticoid therapy at a physiological dose after reports of improved response to vasopressor drugs
J. Guerrero +4 more
semanticscholar +1 more source
Glucocorticoid receptors recruit the CaMKIIα, BDNF–CREB pathways to mediate memory consolidation
Nature Neuroscience, 2012 Emotionally important events are well remembered. Although memories of emotional experiences are known to be mediated and modulated by stress hormones such as glucocorticoids, little is known about the underlying molecular mechanisms.
Dillon Y. Chen +3 more
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Glucocorticoid receptors modulate mitochondrial function
Communicative & Integrative Biology, 2009 It has become increasingly clear that glucocorticoid (GC) signaling not only comprises classic nuclear receptor binding—that is, glucocorticoid receptors (GRs) to their response element in the nucleus—but also involves rapid, non-genomic efforts to ...
Jing Du, B. McEwen, H. Manji
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