Results 31 to 40 of about 2,506,792 (349)
Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword
Cells, 2013 First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates +1 more
doaj +1 more source
Localization of mineralocorticoid receptors at mammalian synapses. [PDF]
PLoS ONE, 2010 In the brain, membrane associated nongenomic steroid receptors can induce fast-acting responses to ion conductance and second messenger systems of neurons.
Eric M Prager +4 more
doaj +1 more source
Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex. [PDF]
, 2018 Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramidal ...
Bruce S. McEwen +8 more
core +2 more sources
Neurobiology of Stress, 2022 ‘You can't roll the clock back and reverse the effects of experiences' Bruce McEwen used to say when explaining how allostasis labels the adaptive process.
Nikolaos P. Daskalakis +2 more
doaj +1 more source
Comparing the rules of engagement of androgen and glucocorticoid receptors
Cellular and Molecular Life Sciences, 2017 Despite the diverse physiological activities of androgens and glucocorticoids, the corresponding receptors are very close members of the nuclear-receptor super family.
F. Claessens, S. Joniau, C. Helsen
semanticscholar +1 more source
Targeting the Stress System During Gestation: Is Early Handling a Protective Strategy for the Offspring? [PDF]
, 2020 The perinatal window is a critical developmental time when abnormal gestational stimuli may alter the development of the stress system that, in turn, influences behavioral and physiological responses in the newborns.
Brancato, Anna +3 more
core +3 more sources
The glucocorticoid hypothesis of depression: history and perspectives
Вавиловский журнал генетики и селекции, 2016 An abnormality in adaptation to negative life events is considered as one of the main causes of the development of depressive symptoms.
G. T. Shishkina, N. N. Dygalo
doaj +1 more source
Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder
Translational Psychiatry, 2014 Some individuals suffering from posttraumatic stress disorder (PTSD) exhibit lower basal salivary cortisol and higher glucocorticoid receptor (GR) sensitivity. Recent studies suggest that epigenetic mechanisms regulate the activity of cortisol and GR. As
B. Labonté +4 more
semanticscholar +1 more source
Evolution of glucocorticoid receptors with different glucocorticoid sensitivity [PDF]
Journal of Endocrinology, 2006 Glucocorticoids (GCs) are commonly used to treat a variety of immune diseases. However, the efficacy of treatment is greatly influenced by an individual variation in sensitivity to GCs, which is caused by differences in the glucocorticoid receptor (GR). The variable receptor profile results from variations in the GR gene, or alternative splicing of the
Gert Flik +4 more
openaire +5 more sources
Cellular and Molecular Life Sciences, 2014 Adult neurogenesis, the birth of new neurons in the mature brain, has attracted considerable attention in the last decade. One of the earliest identified and most profound factors that affect adult neurogenesis both positively and negatively is stress ...
D. Saaltink, E. Vreugdenhil
semanticscholar +1 more source