Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies [PDF]
, 2018 Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL).
Beck, Ilse +5 more
core +3 more sources
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay. [PDF]
, 2017 BackgroundGlucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors.
Block, Thaddeus S +4 more
core +2 more sources
Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
PLoS ONE, 2014 The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson +2 more
doaj +1 more source
Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. [PDF]
PLoS ONE, 2014 Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating glucocorticoid receptors and binding to glucocorticoid response elements.
Qin Xue +3 more
doaj +1 more source
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]
Journal of Integrative Neuroscience, 2020 Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
doaj +1 more source
Cell Reports, 2018 Summary: Steroid hormone receptors are simultaneously active in many tissues and are capable of altering each other’s function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus, and their ligands have opposing effects
Jeffery M. Vahrenkamp +10 more
doaj +1 more source
Steroids, Pregnancy and Fetal Development
Frontiers in Immunology, 2020 Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone, increases.
Maria Emilia Solano, Petra Clara Arck
doaj +1 more source
The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]
, 2015 Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien +3 more
core +2 more sources
Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on glucocorticoid and ß-adrenergic activity. [PDF]
PLoS ONE, 2012 BACKGROUND: Glucocorticoid hormones, in interaction with noradrenaline, enable the consolidation of emotionally arousing and stressful experiences in rodents and humans.
Ratna Angela Sarabdjitsingh +4 more
doaj +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources