Results 61 to 70 of about 2,388,695 (167)

Steroid Receptors and Vertebrate Evolution [PDF]

arXiv, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv  

Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.

Blood, 2007
To explore the role of glucocorticoids in regulation of kinase pathways during innate immune responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in macrophages (MGRKO).
Sandip Bhattacharyya, Diane E. Brown, J. Brewer, S. Vogt, L. Muglia   +4 more
semanticscholar   +1 more source

Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy

Neurobiology of Stress, 2022
‘You can't roll the clock back and reverse the effects of experiences' Bruce McEwen used to say when explaining how allostasis labels the adaptive process.
Nikolaos P. Daskalakis, Onno C. Meijer, E. Ron de Kloet   +2 more
doaj  

Distribution and Abundance of Glucocorticoid and Mineralocorticoid Receptors throughout the Brain of the Great Tit (Parus major). [PDF]

PLoS ONE, 2016
The glucocorticoid stress response, regulated by the hypothalamic-pituitary-adrenal (HPA) axis, enables individuals to cope with stressors through transcriptional effects in cells expressing the appropriate receptors.
Rebecca A Senft, Simone L Meddle, Alexander T Baugh   +2 more
doaj   +1 more source

A Thermodynamic Model for Receptor Clustering [PDF]

, 1999
Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv   +1 more source

Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo.

Journal of Clinical Investigation, 1995
We investigated the in vivo effects of a glucocorticoid on beta-agonist-induced downregulation of beta 1- and beta 2-adrenergic receptors (determined by [125I]iodocyanopindolol binding), mRNA expression (assessed by Northern blotting), and gene ...
Judith, C. W. Mak, M. Nishikawa, H. Shirasaki, K. Miyayasu, Peter, J. Barnes   +6 more
semanticscholar   +1 more source

A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors

Ecotoxicology and Environmental Safety, 2021
Production of polychlorinated biphenyls (PCBs) was banned a long time ago because of their harmful health effects but humans continue to be exposed to residual PCBs in the environment.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj  

Early Life Stress Effects on the Glucocorticoid - BDNF interplay in the Hippocampus

Frontiers in Molecular Neuroscience, 2015
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important biological effects of ELS are manifested in stress-susceptible regions of the hippocampus and are partially mediated by long-term effects on glucocorticoid
Nikolaos P Daskalakis, Edo Ronald eDe Kloet, Rachel eYehuda, Dolores eMalaspina, Thorsten M. Kranz   +4 more
doaj   +1 more source

Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling

Stem Cell Research & Therapy, 2021
Background Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to and from the bone marrow (BM) is a
Wenting Gao, Xuetao Yang, Juan Du, Haiyan Wang, Hejiang Zhong, Jianxin Jiang, Ce Yang   +6 more
doaj   +1 more source

11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.

Physiological Reviews, 2013
Glucocorticoid action on target tissues is determined by the density of "nuclear" receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyze interconversion of active cortisol and ...
K. Chapman, M. Holmes, J. Seckl
semanticscholar   +1 more source