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The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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Cross-talk and regulation between glutamate and GABAB receptors [PDF]
Frontiers in Cellular Neuroscience, 2015 Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease
Frontiers in Neuroscience, 2020 Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang +10 more
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Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence?
Frontiers in Neuroscience, 2015 Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
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Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
Frontiers in Molecular Neuroscience, 2019 Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve injury is long lasting and responsible for long-term disability in ...
Vanessa Pereira, Cyril Goudet
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mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy [PDF]
Frontiers in Bioscience-LandmarkGlutamate is an important neurotransmitter in the mammalian brain. Among the receptors that glutamate interacts with is metabotropic glutamate (mGlu) receptor 2, a Gαi/o-coupled receptor.
Li-Min Mao +2 more
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Astroglial Glutamate Signaling and Uptake in the Hippocampus
Frontiers in Molecular Neuroscience, 2018 Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond
Christine R. Rose +7 more
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Modeling the use of transient ligand binding information by AMPA receptors [PDF]
npj Systems Biology and ApplicationsGlutamate mediates fast excitatory neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors in the central nervous system.
Helena Braunstein +2 more
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Plants, 2022 Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz +7 more
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The role of glutamate receptors in the regulation of the tumor microenvironment
Frontiers in Immunology, 2023 Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda +8 more
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