The Role of Glutamate Receptors in Epilepsy
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen+3 more
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Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease
Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Shaogang Qu
exaly +4 more sources
Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Jan Lewerenz, Pamela Maher
exaly +4 more sources
Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in
Background Drosophila discs-large (DLG) is the sole representative of a large class of mammalian MAGUKs, including human DLG, SAP 97, SAP102, and PSD-95. MAGUKs are thought to be critical for postsynaptic assembly at glutamatergic synapses.
Featherstone David E, Chen Kaiyun
doaj +4 more sources
Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
doaj +9 more sources
Cross-talk and regulation between glutamate and GABAB receptors [PDF]
Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
Scheppach, Christian
arxiv +3 more sources
Posttranslational Modification Biology of Glutamate Receptors and Drug Addiction [PDF]
Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active ...
Li-Min eMao+5 more
doaj +4 more sources
Researching glutamate – induced cytotoxicity in different cell lines: a comparative/, collective analysis/study [PDF]
Although glutamate is one of the most important excitatory neurotransmitters of the central nervous system, its excessive extracellular concentration leads to uncontrolled continuous depolarization of neurons, a toxic process called, excitotoxicity.
Aristeidis eKritis+3 more
doaj +3 more sources
Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. [PDF]
Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic calcium concentration at hippocampal synapses, resulting in various types of changes in synaptic strength.
Renaud Greget+13 more
doaj +7 more sources