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Cross-talk and regulation between glutamate and GABAB receptors [PDF]
Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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The Role of Glutamate Receptors in Epilepsy
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen+3 more
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Modeling the use of transient ligand binding information by AMPA receptors [PDF]
Glutamate mediates fast excitatory neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors in the central nervous system.
Helena Braunstein+2 more
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Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz+7 more
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The role of glutamate receptors in the regulation of the tumor microenvironment
Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda+8 more
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Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
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Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Eisenman, Larry+3 more
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Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease
Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang+10 more
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Afferent convergence to a shared population of interneuron AMPA receptors
Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission ...
Reagan L. Pennock+4 more
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Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. [PDF]
Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic calcium concentration at hippocampal synapses, resulting in various types of changes in synaptic strength.
Renaud Greget+13 more
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