Results 131 to 140 of about 2,618,718 (368)

Acute effects of ethanol on glutamate receptors.

Basic & Clinical Pharmacology & Toxicology, 2012
Several studies have revealed that acute ethanol inhibits the function of glutamate receptors. Glutamate receptor-mediated synaptic plasticity, such as N-methyl-D-aspartate-dependent long-term potentiation, is also inhibited by ethanol.
Tommi Möykkynen, E. Korpi
semanticscholar   +1 more source

D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity

Advanced Science, EarlyView.
Downregulating D‐2‐hydroxyglutarate dehydrogenase (D2HGDH) increases epilepsy susceptibility by altering reactive oxygen species (ROS) levels and synaptic function, contributing to oxidative stress in neurons. The acid calcium‐independent phospholipase A2 (aiPLA2) inhibitor MJ33 restores glutathione reduced/glutathione oxidized balance, reducing ROS ...
Zhijuan Zhang, Hui Zhang, Peng Zhang, Rong Li, Jinyu Zhou, Jiyuan Li, Danmei Hu, Rui Huang, Fenglin Tang, Jie Liu, Demei Xu, Chenlu Zhang, Xin Tian, Yuanlin Ma, Patrick Kwan   +14 more
wiley   +1 more source

Mucous Permeable Nanoparticle for Inducing Cuproptosis‐Like Death In Broad‐Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia

Advanced Science, EarlyView.
Copper‐based nanoparticles doped with BSO, and modified with PEG, not only can it increase the retention ability and mucosal penetration ability in the lungs, but also induce cuproptosis‐like death in bacteria and inhibit bacterial TCA cycle. It can also inhibit bacterial quorum sensing, clear biofilms, reduce bacterial virulence, and thus exert ...
Huiqun Hu, Shiyuan Hua, Feng Lu, Wenting Zhang, Zengwen Zhang, Jiarong Cui, Xiaoyue Lei, Jingyan Xia, Feng Xu, Min Zhou   +9 more
wiley   +1 more source

Stochastic Turing pattern formation in a model with active and passive transport [PDF]

arXiv, 2020
We investigate Turing pattern formation in a stochastic and spatially discretized version of a reaction diffusion advection (RDA) equation, which was previously introduced to model synaptogenesis in \textit{C. elegans}. The model describes the interactions between a passively diffusing molecular species and an advecting species that switches between ...
arxiv  

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

MicroRNA-223 is neuroprotective by targeting glutamate receptors

Proceedings of the National Academy of Sciences of the United States of America, 2012
Stroke is a major cause of mortality and morbidity worldwide. Extracellular glutamate accumulation leading to overstimulation of the ionotropic glutamate receptors mediates neuronal injury in stroke and in neurodegenerative disorders.
Maged M. Harraz, S. Eacker, Xueqing Wang, T. Dawson, V. Dawson   +4 more
semanticscholar   +1 more source

Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory

Advanced Science, EarlyView.
Li et al. defined two novel glutamatergic neuronal subtypes in the medial mammillary nucleus, pars lateralis‐located parvalbumin (PV) neurons, and basalis‐located Drd2 neurons. PV and Drd2 neurons differ in their electrophysiological properties encoded by Kcnn4 and Cacna1h, and selectively modulate place and object recognition memory by two distinct ...
Lanfang Li, Yiqing Guo, Wei Jing, Xiaomei Tang, Jinyu Zeng, Zhenye Hou, Yige Song, Aodi He, Hao Li, Ling‐Qiang Zhu, Youming Lu, Xinyan Li   +11 more
wiley   +1 more source

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran, Rosaria Gitto   +4 more
wiley   +1 more source

Transcranial Bipolar Direct Current Stimulation of the Frontoparietal Cortex Reduces Ketamine-Induced Oscillopathies: A Pilot Study in the Sedated Rat [PDF]

arXiv, 2020
Running title: Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies.Abstract: During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies).
arxiv  

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, EarlyView.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source