Results 11 to 20 of about 294,964 (311)

Simulation of postsynaptic glutamate receptors reveals critical features of glutamatergic transmission. [PDF]

PLoS ONE, 2011
Activation of several subtypes of glutamate receptors contributes to changes in postsynaptic calcium concentration at hippocampal synapses, resulting in various types of changes in synaptic strength.
Renaud Greget, Fabien Pernot, Jean-Marie C Bouteiller, Viviane Ghaderi, Sushmita Allam, Anne Florence Keller, Nicolas Ambert, Arnaud Legendre, Merdan Sarmis, Olivier Haeberle, Michel Faupel, Serge Bischoff, Theodore W Berger, Michel Baudry   +13 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila

BMC Biology, 2005
Background Drosophila discs-large (DLG) is the sole representative of a large class of mammalian MAGUKs, including human DLG, SAP 97, SAP102, and PSD-95. MAGUKs are thought to be critical for postsynaptic assembly at glutamatergic synapses.
Featherstone David E, Chen Kaiyun
doaj   +1 more source

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
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Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors

Frontiers in Cellular Neuroscience, 2019
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun, Yongjun Sun, Xue Feng, Yue Ding, Mengting Li, Jun Yao, Long Wang, Zibin Gao, Zibin Gao   +8 more
doaj   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
A. Wade, Berger, Bergeron, Billups, Burlina, Bzdega, Chakraborty, Chatterton, D'Angelo, D. Attwell, Fenwick, Fields, Follett, Jakobs, Jane, K. Kolodziejczyk, Karadottir, Karadottir, Khwaja, Koenig, Kumar, K  rad  ttir, Li, Micu, N. B. Hamilton, Pliss, R. Karadottir, Rubin, Salter, Sartori, Sekiguchi, Tortella, Valivullah, Westbrook, Wevers, Wolf, Wroblewska   +36 more
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Glutamate Receptors in Plants [PDF]

Annals of Botany, 2002
Ionotropic glutamate receptors function in animals as glutamate-gated non-selective cation channels. Numerous glutamate receptor-like (GLR) genes have been identified in plant genomes, and plant GLRs are predicted, on the basis of sequence homology, to retain ligand-binding and ion channel activity. Non-selective cation channels are ubiquitous in plant
openaire   +3 more sources

Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]

PLoS ONE, 2014
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Elżbieta Salińska, Lidia Strużyńska   +3 more
doaj   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources