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The role of immunoglobulin E in non-atopic disorders [PDF]
Frontiers in ImmunologyImmunoglobulin E (IgE) and its corresponding Fc epsilon receptors (FcϵRs) are essential components of the immune system. The constant, crystallizable fragment (Fc) region of IgE binds with high affinity to its specific receptor, FcϵRI, anchoring IgE ...
Kujtim Thaçi +4 more
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Frontiers in Allergy, 2023 It is well established that immunoglobulin E (IgE) plays a crucial role in atopy by binding to two types of Fcε receptors (FcεRI and FcεRII, also known as CD23).
Kevin Plattner +6 more
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Frontiers in Plant Science, 2022 Omalizumab, the anti-immunoglobulin IgE antibody is the only approved and available monoclonal antibody as an auxiliary medicament for the severe respiratory allergic reactions.
Oranicha Hanittinan +11 more
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IgE glycans promote anti-IgE IgG autoantibodies that facilitate IgE serum clearance via Fc Receptors
Frontiers in Immunology, 2022 BackgroundRecent studies have shown that IgE glycosylation significantly impacts the ability of IgE to bind to its high-affinity receptor FcεRI and exert effector functions. We have recently demonstrated that immunizing mice with IgE in a complex with an
Kevin Plattner +11 more
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Relationships between levels of serum IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population. [PDF]
PLoS ONE, 2010 Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to cell surface receptors such as FcepsilonRI and
Eleonora Dehlink +4 more
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The Effector Function of Allergens
Frontiers in Allergy, 2022 Allergens are antigens that generate an IgE response (sensitization) in susceptible individuals. The allergenicity of an allergen can be thought of in terms of its ability to sensitize as well as its ability to cross-link IgE/IgE receptor complexes on ...
Stéphane Hazebrouck +2 more
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The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]
PLoS ONE, 2013 BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth +5 more
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Soluble IgE receptors—Elements of the IgE network [PDF]
Immunology Letters, 2011 Soluble isoforms of three human IgE Fc receptors, namely FcεRI, FcεRII, and galectin-3, can be found in serum. These soluble IgE receptors are a diverse family of proteins unified by the characteristic of interacting with IgE in the extracellular matrix.
Barbara, Platzer +3 more
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Fc receptors for immunoglobulins and their appearance during vertebrate evolution. [PDF]
PLoS ONE, 2014 Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as ...
Srinivas Akula +2 more
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Biomedicines, 2023 Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). Chemokine receptors such as chemokine (C-C motif) receptor 4 (CCR4) or CCR8 have been studied in skin diseases, e.g., atopic dermatitis, but ...
Ewa A. Bartko +4 more
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