Results 1 to 10 of about 298,366 (246)

Structural and dynamic properties of IL1 receptors [PDF]

Frontiers in Immunology
The study of the structural and dynamic properties of multidomain proteins is of great interest as they constitute one of the main regulatory mechanisms in the ligand–receptor system.
J. V. Zhukova, J. A. Lopatnikova, S. V. Sennikov   +2 more
doaj   +2 more sources

Expression of Interleukin-1 and Interleukin-1 Receptors Type 1 and Type 2 in Hodgkin Lymphoma. [PDF]

PLoS ONE, 2015
Signaling through the IL-1-receptor type 1 (IL-1R1), IL-1 is required for initiation and maintenance of diverse activities of the immune system. A second receptor, IL-1R2, blocks IL-1 signal transduction. We studied expression of IL-1beta, IL-1R1, and IL-
Elisabeth Oelmann, Harald Stein, Wolfgang E Berdel, Hermann Herbst   +3 more
doaj   +1 more source

Presence of interleukin-8 and the IL-1 receptor antagonist in the cervical mucus of fertile and infertile women [PDF]

Vojnosanitetski Pregled, 2004
Background. Cytokines are involved in almost every aspect of reproduction and recent studies suggested a relationship between cytokines and male/female infertility.
Kataranovski Milena, Radojčić Ljiljana, Prokić Vera, Vojvodić Danilo   +3 more
doaj   +1 more source

Perspective: Daniela Novick, cytokines and their receptors

Frontiers in Immunology, 2023
This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several ...
Pietro Ghezzi, Giamila Fantuzzi, Charles A. Dinarello   +2 more
doaj   +1 more source

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice

Frontiers in Neurology, 2021
Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial reactivity.
Federica Mastroiacovo, Manuela Zinni, Giada Mascio, Valeria Bruno, Valeria Bruno, Giuseppe Battaglia, Giuseppe Battaglia, Julien Pansiot, Tiziana Imbriglio, Jerome Mairesse, Jerome Mairesse, Olivier Baud, Olivier Baud, Olivier Baud, Ferdinando Nicoletti, Ferdinando Nicoletti   +15 more
doaj   +1 more source

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease

Frontiers in Immunology, 2022
Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity, receptor antagonists, and an anti-inflammatory cytokine.
Domenico Supino, Luna Minute, Luna Minute, Andrea Mariancini, Andrea Mariancini, Federica Riva, Elena Magrini, Cecilia Garlanda, Cecilia Garlanda   +8 more
doaj   +1 more source

Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat [PDF]

Diabetes & Metabolism Journal
Background The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM).
Serena Boccella, Andrea Maria Morace, Cristina Giorgio, Francesca Guida, Michela Perrone, Iolanda Manzo, Carmela Belardo, Meghan Jones, Sabatino Maione, Andrea Aramini, Marcello Allegretti, Livio Luongo, Laura Brandolini   +12 more
doaj   +1 more source

Suppression of interleukin-1 beta and LDL scavenger receptor expression in macrophages by a selective protein kinase C inhibitor.

Journal of Lipid Research, 1991
A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (
AL Akeson, K Schroeder, C Woods, CJ Schmidt, W D Jones   +4 more
doaj   +1 more source

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells

Frontiers in Immunology, 2019
The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo, David Klatzmann, David Klatzmann   +2 more
doaj   +1 more source

Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study

Critical Care Explorations, 2022
OBJECTIVES:. This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers.
Raquel Bragante Gritte, PhD, Talita Souza-Siqueira, PhD, Eliane Borges da Silva, PhD, Laiane Cristina dos Santos de Oliveira, PhD, Rodrigo Cerqueira Borges, PhD, Heloísa H de Oliveira Alves, PhD, Laureane Nunes Masi, PhD, Gilson Masahiro Murata, PhD, Renata Gorjão, PhD, Adriana Cristina Levada-Pires, PhD, Antônio Carlos Nogueira, PhD, Tânia Cristina Pithon-Curi, PhD, Ricardo Bentes de Azevedo, PhD, Francisco Garcia Soriano, MD, PhD, Rui Curi, PhD, Marcel Cerqueira Cesar Machado, MD, PhD   +15 more
doaj   +1 more source