Results 21 to 30 of about 312,920 (268)

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

Journal of Biological Chemistry, 1991
The interleukin-1 receptor antagonist (IL-1ra) inhibits the binding of interleukin-1 (IL-1) to T-cell lines possessing the type I IL-1 receptor; evidence has been published (Carter, D. B., Deibel, M. R. J., Dunn, C. J., Tomich, C. S., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., Harris, P. K. W., Yem, A.
E V, Granowitz, B D, Clark, J, Mancilla, C A, Dinarello   +3 more
openaire   +2 more sources

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Frontiers in Genetics
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β ...
Jia-wei Ma, Jia-wei Ma, Ji-chun Tang, Hong-zhi Fang   +3 more
doaj   +1 more source

PROMOTER POLYMORPHISMS OF GENES ENCODING TUMOR NECROSIS FACTOR AND INTERLEUKIN-1 IN BREAST CANCER PATIENTS

Медицинская иммунология, 2017
Search for molecular genetic markers of risk and prognosis of breast cancer is an important prospective of modern research. Many molecular mechanisms are involved in pathogenesis of breast cancer and define a wide range of possible candidate genes.
A. N. Silkov, N. V. Cherdyntseva, V. N. Maximov, S. V. Sennikov   +3 more
doaj   +1 more source

Interleukin‐1 receptor accessory protein interacts with the type II interleukin‐1 receptor

FEBS Letters, 1998
Stably transfected HEK‐293 cells express on their surface the murine type II IL‐1 receptor (mIL‐1RII) as demonstrated by FACS analysis using the mAb 4E2, however binding of [125I]‐hrIL‐1β to these cells is nearly absent. Saturable high affinity binding of [125I]‐hrIL‐1β is observed when the murine IL‐1 receptor accessory protein (mIL‐1RAcP) is ...
Malinowsky, David, Lundkvist, Johan, Layé, Sophie, Bartfai, Tamas   +3 more
openaire   +2 more sources

Influence of Simvastatin and Interleukin 1 Receptor Antagonist on Expression of Aryl Hydrocarbon Receptors Under Experimental Acute Ileitis

Gastroenterologìa, 2015
Aryl hydrocarbon receptor (AhR) — transcription factor activated by a large number of environmental agents, and may play a role in the pathogenesis of inflammatory bowel diseases in humans and mouse models.
O.S. Zherebiatiev, O.M. Kamyshnyi
doaj   +1 more source

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

Journal of Hematology & Oncology, 2012
The discovery of miRNAs has revolutionized the way we examine the genome, RNA products, and the regulation of transcription and translation. Their ability to modulate protein expression through mRNA degradation and translation repression resulted in avid
Virtue Anthony, Wang Hong, Yang Xiao-feng   +2 more
doaj   +1 more source

Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein [PDF]

Proceedings of the National Academy of Sciences, 1997
The proinflammatory cytokine interleukin 1 (IL-1) activates the transcription of many genes encoding acute phase and proinflammatory proteins, a function mediated primarily by the transcription factor NF-κB. An early IL-1 signaling event is the recruitment of the Ser/Thr kinase IRAK to the type I IL-1 receptor (IL-1RI). Here we describe the function of
J, Huang, X, Gao, S, Li, Z, Cao
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The interleukin‐1 receptor antagonist influences interleukin‐1 effects in rat and mouse [PDF]

Mediators of Inflammation, 1992
In this work we have focused on the ability of interleukin‐1 to induce an acute phase protein response and a degranulation of polymorphonuclear leukocytes in vivo. The capacity of the interleukin‐1 receptor antagonist to influence these events was also investigated.
P. Bjrök, K. Ohlsson
openaire   +3 more sources