Results 11 to 20 of about 312,920 (268)

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

Cell Reports, 2020
Summary: Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate of cardiovascular events.
Louise Ménégaut, Charles Thomas, Antoine Jalil, Jean Baptiste Julla, Charlène Magnani, Adam Ceroi, Louise Basmaciyan, Adélie Dumont, Wilfried Le Goff, Mano Joseph Mathew, Cédric Rébé, Valentin Dérangère, Aline Laubriet, Valentin Crespy, Jean-Paul Pais de Barros, Eric Steinmetz, Nicolas Venteclef, Philippe Saas, Laurent Lagrost, David Masson   +19 more
doaj   +1 more source

Frontiers in Drug Research and Development for Inflammatory Bowel Disease

Frontiers in Pharmacology, 2017
Inflammatory bowel disease (IBD) is idiopathic, lifelong, immune-mediated diseases, for which curative therapies are not yet available. In the last 15 years, the introduction of monoclonal antibodies targeting tumor necrosis factor-α, a cytokine playing ...
Diego Currò, Daniela Pugliese, Alessandro Armuzzi   +2 more
doaj   +1 more source

Biology of the Interleukin-1 Receptor

Journal of Investigative Dermatology, 1990
The biological effects of the two interleukin-1s on cells of connective tissue origin are mediated by specific cell-surface receptors. Molecular cloning studies have revealed that these receptors are identical in protein sequence to the IL-1 receptors on cells of the T-lymphocyte lineage. The functional interleukin-1 receptor on T-cells and fibroblasts
Dower, Steven K, Qwarnstrom, Eva E, Page, Roy C, Blanton, Rebecca A, Kupper, Thomas S, Raines, Elaine, Ross, Russell, Sims, John E   +7 more
openaire   +2 more sources

Interleukin-1 receptors and receptor antagonist in haemodialysis [PDF]

Nephrology Dialysis Transplantation, 1997
Biological activity of interleukin-1 (IL-1) depends on the number and type of IL-1 receptors on target cells and on the amounts of its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1ra).Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic ...
D, Donati, D, Degiannis, E, Mazzola, L, Gastaldi, J, Raskova, K, Raska, G, Camussi   +6 more
openaire   +2 more sources

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

Journal of Neuroinflammation, 2018
Background Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the function of astrocytes was previously
Xiaosong He, Yanqun Liu, Xiaohong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan, Guo-Yuan Yang   +8 more
doaj   +1 more source

Mendelian randomization study of interleukin (IL)-1 family and lung cancer

Scientific Reports, 2021
The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding.
Zhao Yang, C. Mary Schooling, Man Ki Kwok   +2 more
doaj   +1 more source

Atopic march in pediatrics: genotype-associated mechanisms Part 1. Genotype-associated mechanisms of the atopic march in children

Zdorovʹe Rebenka, 2017
The review deals with the data of studies over last 10 years of populations of different countries on association of atopic diseases being the components of the atopic march in children (atopic eczema, allergic rhinitis, allergic rhinoconjunctivitis ...
V.O. Dytiatkovsky
doaj   +1 more source

Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response

Cells, 2020
Amniotic epithelial cells (AEC) have been proposed as promising clinical candidates for regenerative medicine therapies due to their immunomodulatory capacity.
Luana Greco, Valentina Russo, Cinzia Rapino, Clara Di Germanio, Filomena Fezza, Nicola Bernabò, Paolo Berardinelli, Alessia Peserico, Domenico Fazio, Mauro Maccarrone, Mauro Mattioli, Barbara Barboni   +11 more
doaj   +1 more source

What Is IL-1 for? The Functions of Interleukin-1 Across Evolution

Frontiers in Immunology, 2022
Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly produced by macrophages during defensive reactions. In mammals, IL-1 is a superfamily of eleven structurally similar proteins, all involved in inflammation or its ...
Diana Boraschi, Diana Boraschi, Diana Boraschi   +2 more
doaj   +1 more source

The Inflammasome in Host Defense

Sensors, 2009
Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome,
Gang Chen, Joao H.F. Pedra
doaj   +1 more source