Results 11 to 20 of about 503,937 (310)

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells

Frontiers in Immunology, 2019
The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo, David Klatzmann, David Klatzmann   +2 more
doaj   +1 more source

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

Cell Reports, 2020
Summary: Low-grade inflammation is constitutive of atherosclerosis, and anti-inflammatory therapy inhibiting interleukin-1β (IL-1β) reduces the rate of cardiovascular events.
Louise Ménégaut, Charles Thomas, Antoine Jalil, Jean Baptiste Julla, Charlène Magnani, Adam Ceroi, Louise Basmaciyan, Adélie Dumont, Wilfried Le Goff, Mano Joseph Mathew, Cédric Rébé, Valentin Dérangère, Aline Laubriet, Valentin Crespy, Jean-Paul Pais de Barros, Eric Steinmetz, Nicolas Venteclef, Philippe Saas, Laurent Lagrost, David Masson   +19 more
doaj   +1 more source

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy. [PDF]

, 2019
Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming.
Canter, Robert J, Gingrich, Alicia A, Modiano, Jaime F   +2 more
core   +2 more sources

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells [PDF]

, 2012
Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells.
Akira, Anderson, Anna Karolina Palucka, Anne O’Garra, Anne-Laure Flamar, Awasthi, Bacchetta, Banchereau, Banchereau, Barrat, Baumgart, Bergman, Brown, Caparrós, Caux, Dapeng Li, Delneste, Dillon, Dorothée Duluc, Dudziak, Feng, Figdor, Gabrielle Romain, Gabrysová, Geijtenbeek, Geijtenbeek, Gerard Zurawski, Geurtsen, Gringhuis, Gringhuis, Groux, Häringer, Ito, Jacques Banchereau, Jankovic, Kaiser, Kappos, Klechevsky, LeibundGut-Landmann, Levings, Macián, Maldonado-López, Melissa Dullaers, Moore, Nathalie Bosquet, Ni, O’Garra, Pulendran, Reddy, Rissoan, Roger Le Grand, Rogers, Roncarolo, Sagoo, Saijo, Sandra Zurawski, SangKon Oh, Saraiva, Saraiva, Schreiber, Shortman, Smits, Soares, Steinman, Trinchieri, Valladeau, Xiao-Hua Li   +66 more
core   +2 more sources

The P2X7 Receptor-Interleukin-1 Liaison [PDF]

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies, such as type II diabetes, gout and atherosclerosis.
GIULIANI, Anna Lisa, SARTI, Alba Clara, FALZONI, Simonetta, DI VIRGILIO, Francesco   +3 more
openaire   +3 more sources

Frontiers in Drug Research and Development for Inflammatory Bowel Disease

Frontiers in Pharmacology, 2017
Inflammatory bowel disease (IBD) is idiopathic, lifelong, immune-mediated diseases, for which curative therapies are not yet available. In the last 15 years, the introduction of monoclonal antibodies targeting tumor necrosis factor-α, a cytokine playing ...
Diego Currò, Daniela Pugliese, Alessandro Armuzzi   +2 more
doaj   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Biology of the Interleukin-1 Receptor

Journal of Investigative Dermatology, 1990
The biological effects of the two interleukin-1s on cells of connective tissue origin are mediated by specific cell-surface receptors. Molecular cloning studies have revealed that these receptors are identical in protein sequence to the IL-1 receptors on cells of the T-lymphocyte lineage. The functional interleukin-1 receptor on T-cells and fibroblasts
Dower, Steven K, Qwarnstrom, Eva E, Page, Roy C, Blanton, Rebecca A, Kupper, Thomas S, Raines, Elaine, Ross, Russell, Sims, John E   +7 more
openaire   +2 more sources

Interleukin-1 receptors and receptor antagonist in haemodialysis [PDF]

Nephrology Dialysis Transplantation, 1997
Biological activity of interleukin-1 (IL-1) depends on the number and type of IL-1 receptors on target cells and on the amounts of its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1ra).Expression of IL-1 receptor was studied on the peripheral blood mononuclear cells of 20 end-stage renal-disease patients maintained by chronic ...
DONATI D., DEGIANNIS D., MAZZOLA E., GASTALDI L., RASKOVA J., RASKA K., CAMUSSI, Giovanni   +6 more
openaire   +3 more sources

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source