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Interleukin-1 receptor antagonist
2000Interleukin-1 (IL-1) is a proinflammatory cytokine produced by a wide variety of cell types with an equally pleiotropic range of activities including the induction of fever, hypotension, adhesion molecule expression, neutrophilia, cartilage destruction, prostanoid production, and induction of the expression of a number of other cytokines. Two forms of
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The interleukin-1/interleukin-1-receptor interaction
Annales de l'Institut Pasteur / Immunologie, 1987J.W. Lowenthal, H.R. MacDonald
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The Role of the Interleukin-1–Receptor Antagonist in Blocking Inflammation Mediated by Interleukin-1
New England Journal of Medicine, 2000Approaches involving the blockade of inflammatory cytokines such as interleukin-1 and tumor necrosis factor α (TNF-α) are entering mainstream clinical medicine: antibodies against TNF-α and soluble...
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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19
New England Journal of Medicine, 2021Michelle A Detry+2 more
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Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases
Frontiers in Pharmacology, 2021Ai-ping Wang
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Interleukin-1-Induced Hypotension and the Effect of an Interleukin-1 Receptor Antagonist
1993The systemic effects of high doses (> 1μg/kg) of intravenously administered interleukin (IL-1) in animals include hypotension, decreased systemic vascular resistance, depressed myocardial function, lactic acidosis, leukopenia, thrombocytopenia, vascular leak, pulmonary congestion, and tissue neutrophilic infiltration with necrosis [1, 2].
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Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis
New England Journal of Medicine, 2021Allan L Klein+2 more
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Interleukin-1 and interleukin-1 receptor antagonist: From bench to bedside
Inflammatory Bowel Diseases, 1996A C, Stevens, M, Peppercorn
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Asymmetrical Expression of Interleukin-1, Interleukin-1 Receptor and Erythropoietin Receptor in Mouse Brain Hemispheres [PDF]
V. V. Abramov+4 more
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