Results 31 to 40 of about 1,451,004 (331)

Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]

, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia, D’Eustachio, Peter, Masci, Anna Maria, Natale, Darren, Ruttenberg, Alan, Shamovsky, Veronica, Smith, Barry, Wu, Cathy   +7 more
core   +4 more sources

Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice

Journal of Neuroinflammation, 2018
Background Netrin-1 functions largely via combined receptors and downstream effectors. Evidence has shown that astrocytes express netrin-1 receptors, including DCC and UNC5H2. However, whether netrin-1 influences the function of astrocytes was previously
Xiaosong He, Yanqun Liu, Xiaohong Lin, Falei Yuan, Dahong Long, Zhijun Zhang, Yongting Wang, Aiguo Xuan, Guo-Yuan Yang   +8 more
doaj   +1 more source

Mendelian randomization study of interleukin (IL)-1 family and lung cancer

Scientific Reports, 2021
The role of interleukin (IL)-1 family members/receptors in lung cancer remains uncertain due to the susceptibility of observed associations to confounding.
Zhao Yang, C. Mary Schooling, Man Ki Kwok   +2 more
doaj   +1 more source

Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors

Journal of Experimental Medicine, 1982
The mechanism by which human C5a anaphylatoxin augments the primary humoral response of murine splenocytes to antigen has been investigated. Culture supernatants were generated from splenic adherent cells or macrophage cell lines after exposure to a ...
M. Goodman, D. Chenoweth, W. Weigle
semanticscholar   +1 more source

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source

Atopic march in pediatrics: genotype-associated mechanisms Part 1. Genotype-associated mechanisms of the atopic march in children

Zdorovʹe Rebenka, 2017
The review deals with the data of studies over last 10 years of populations of different countries on association of atopic diseases being the components of the atopic march in children (atopic eczema, allergic rhinitis, allergic rhinoconjunctivitis ...
V.O. Dytiatkovsky
doaj   +1 more source

Interleukin-38 and cardiovascular pathology: literature review [PDF]

КардиоСоматика, 2023
Cardiovascular pathology is a leading cause of morbidity and mortality. An important task of modern cardiology is the search and study of new biological markers. Scientists’ interest is actively focused on the study of interleukin-38.
Amina M. Alieva, Irina E. Baykova, Tatyana V. Pinchuk, Irina A. Kotikova, Igor G. Nikitin   +4 more
doaj   +1 more source

Detection and characterization of high affinity plasma membrane receptors for human interleukin 1

Journal of Experimental Medicine, 1985
Interleukin 1 (IL-1) is a polypeptide hormone that acts as a central mediator of inflammation. Since IL-1 action is presumably mediated by specific cell surface receptor(s), we have characterized the binding of this hormone to cells.
S. Dower, S. Kronheim, C. March, P. Conlon, T. Hopp, S. Gillis, D. Urdal   +6 more
semanticscholar   +1 more source

The Inflammasome in Host Defense

Sensors, 2009
Nod-like receptors have emerged as an important family of sensors in host defense. These receptors are expressed in macrophages, dendritic cells and monocytes and play an important role in microbial immunity. Some Nod-like receptors form the inflammasome,
Gang Chen, Joao H.F. Pedra
doaj   +1 more source

Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response

Cells, 2020
Amniotic epithelial cells (AEC) have been proposed as promising clinical candidates for regenerative medicine therapies due to their immunomodulatory capacity.
Luana Greco, Valentina Russo, Cinzia Rapino, Clara Di Germanio, Filomena Fezza, Nicola Bernabò, Paolo Berardinelli, Alessia Peserico, Domenico Fazio, Mauro Maccarrone, Mauro Mattioli, Barbara Barboni   +11 more
doaj   +1 more source