Results 1 to 10 of about 478,975 (311)

Imprint of Initial Education and Loss of Ly49C/I in Activated Natural Killer Cells of TAP1-KO and C57BL/6 Wildtype Mice

Frontiers in Immunology, 2022
Natural killer (NK) cells are important effectors of the innate immune system and participate in the first line of defense against infections and tumors.
Neha D. Patil, Neha D. Patil, Olivia Domingues, Cécile Masquelier, Maud Theresine, Oceane Schlienger, Clinton Njinju Amin Asaba, Marine Thomas, Carole Seguin-Devaux, Hortense Slevogt, Markus Ollert, Markus Ollert, Jacques Zimmer   +12 more
doaj   +1 more source

Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future

Frontiers in Immunology, 2021
In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies.
Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Zhijian Ren, Zhijian Ren, Futian Tang, Futian Tang, Yumin Li, Yumin Li   +9 more
doaj   +1 more source

The Effects of Pro-Inflammatory Cytokines on Human Body and Their Relation with Diseases (Review Article)

Academic Science Journal, 2023
Cytokines are important mediators in inflammatory disorders that affect the entire body. Signaling molecules called pro-inflammatory cytokines, also known as inflammatory cytokines, are released by the immune system cells including macrophages and T ...
Khalid Shaalan Sahab , Mohammed Asaad Mahdi, Ammar M. K. AL-Azzawi   +2 more
doaj   +1 more source

Characterization of Endocannabinoid System and Interleukin Profiles in Ovine AEC: Cannabinoid Receptors Type-1 and Type-2 as Key Effectors of Pro-Inflammatory Response

Cells, 2020
Amniotic epithelial cells (AEC) have been proposed as promising clinical candidates for regenerative medicine therapies due to their immunomodulatory capacity.
Luana Greco, Valentina Russo, Cinzia Rapino, Clara Di Germanio, Filomena Fezza, Nicola Bernabò, Paolo Berardinelli, Alessia Peserico, Domenico Fazio, Mauro Maccarrone, Mauro Mattioli, Barbara Barboni   +11 more
doaj   +1 more source

Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study

Critical Care Explorations, 2022
OBJECTIVES:. This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers.
Raquel Bragante Gritte, PhD, Talita Souza-Siqueira, PhD, Eliane Borges da Silva, PhD, Laiane Cristina dos Santos de Oliveira, PhD, Rodrigo Cerqueira Borges, PhD, Heloísa H de Oliveira Alves, PhD, Laureane Nunes Masi, PhD, Gilson Masahiro Murata, PhD, Renata Gorjão, PhD, Adriana Cristina Levada-Pires, PhD, Antônio Carlos Nogueira, PhD, Tânia Cristina Pithon-Curi, PhD, Ricardo Bentes de Azevedo, PhD, Francisco Garcia Soriano, MD, PhD, Rui Curi, PhD, Marcel Cerqueira Cesar Machado, MD, PhD   +15 more
doaj   +1 more source

A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses

Scientific Reports, 2022
T cell-dendritic cell (DC) interactions contribute to reciprocal stimulation leading to DC maturation that results in production of interleukin-12 (IL-12) and interferon-gamma (IFN-γ).
Michael Agrez, Justyna Rzepecka, Darryl Turner, Gavin Knox, Christopher Chandler, Christopher B. Howard, Nicholas Fletcher, Kristofer Thurecht, Stephen Parker, Hayley Gooding, Laura Gallagher   +10 more
doaj   +1 more source

Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models

Nature Communications, 2023
The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies.
Yanping Yang, Huan Yang, Yago Alcaina, Janusz Puc, Alyssa Birt, Yogindra Vedvyas, Michael Gallagher, Srinija Alla, Maria Cristina Riascos, Jaclyn E. McCloskey, Karrie Du, Juan Gonzalez-Valdivieso, Irene M. Min, Elisa de Stanchina, Matt Britz, Eric von Hofe, Moonsoo M. Jin   +16 more
doaj   +1 more source

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]

, 1998
Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao, Simon, Melvin I., Wu, Dianqing, Xie, Wei, Yuan, Huidong   +4 more
core   +1 more source

Structure of the IL-27 quaternary receptor signaling complex

eLife, 2022
Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia   +4 more
doaj   +1 more source

SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS

Медицинская иммунология, 2014
The article presents the results of studies concerning secretion of cytokines belonging to interleukin 12 family, i.e., IL-12р70, IL-12р40, IL-12р35 and IL-27 in mononuclear blood leukocytes, as well as expression of their specific receptors on T ...
I. E. Esimova, O. I. Urazova, V. V. Novitskiy, R. R. Khasanova, O. V. Filinyuk   +4 more
doaj   +1 more source