Results 11 to 20 of about 478,975 (311)

Regulation of Interleukin-12 by Complement Receptor 3 Signaling [PDF]

The Journal of Experimental Medicine, 1997
Complement receptor type 3 (CR3, CD11b/CD18) serves as a receptor for a number of endogenous ligands and infectious organisms, and is involved in adhesion and host defense functions. Here, we report that signaling via CR3 plays an important role in regulating production of interleukin-12 (IL-12), a key mediator of cell-mediated immunity (CMI).
T, Marth, B L, Kelsall
openaire   +2 more sources

Recurrent Salmonella Bacteremia in Interleukin-12 Receptor β1 Deficiency [PDF]

Journal of Tropical Pediatrics, 2006
Interleukin-12 receptor beta1 IL12RB1 deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp.
Ozen, Metehan, Ceyhan, Mehmet, Sanal, Ozden, Bayraktar, Mehmet, Mesci, Luetfiye   +4 more
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Interleukin‐12 Receptor β1 Deficiency in a Patient with Abdominal Tuberculosis [PDF]

The Journal of Infectious Diseases, 2001
Two siblings with interleukin-12 receptor beta1 (IL-12Rbeta1) deficiency but different clinical phenotypes were studied. Both are homozygous for an IL12RB1 missense mutation that prevents receptor expression and abolishes cellular responses to IL-12.
F, Altare, A, Ensser, A, Breiman, J, Reichenbach, J E, Baghdadi, A, Fischer, J F, Emile, J L, Gaillard, E, Meinl, J L, Casanova   +9 more
openaire   +2 more sources

Interleukin-12 Receptor  1 Deficiency Predisposing to Disseminated Coccidioidomycosis [PDF]

Clinical Infectious Diseases, 2011
Severe disseminated Coccidioides is rare while localized, contained disease is common. We report a family with disseminated coccidioidomycosis due to a novel homozygous C186Y mutation in interleukin (IL)-12 receptor β1. This family confirms the centrality of the IL-12/IFN-γ axis to human immunity to Coccidioides spp.
Donald C, Vinh, Brian, Schwartz, Amy P, Hsu, David J, Miranda, Patricia A, Valdez, Danielle, Fink, Karen P, Lau, Debra, Long-Priel, Douglas B, Kuhns, Gulbu, Uzel, Stefania, Pittaluga, Susan, Hoover, John N, Galgiani, Steven M, Holland   +13 more
openaire   +2 more sources

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

Dysregulation of Lymphocyte Interleukin-12 Receptor Expression in Sézary Syndrome [PDF]

Journal of Investigative Dermatology, 2001
Initial phase I and II clinical trials with recombinant human interleukin-12 have demonstrated the therapeutic efficacy of this cytokine in early stage cutaneous T cell lymphoma as compared with more advanced stages such as the leukemic Sézary syndrome.
Zaki, Mohamed H., Shane, Ryan B., Geng, Yuemei, Showe, Louise C., Everetts, Suzanne E., Presky, David H., Wysocka, Maria, Moore, Jonni S., Rook, Alain H.   +8 more
openaire   +2 more sources

Gene Expression Profiling of Peripheral Blood Mononuclear Cells in Type 2 Diabetes: An Exploratory Study

Medicina, 2022
Background and Objectives: Visceral obesity is associated with chronic low-grade inflammation that predisposes to metabolic syndrome. Indeed, infiltration of adipose tissue with immune–inflammatory cells, including ‘classical’ inflammatory M1 and anti ...
Hana M. A. Fakhoury, Muhammad Affan Elahi, Saud Al Sarheed, Mohammed Al Dubayee, Awad Alshahrani, Mahmoud Zhra, Arwa Almassri, Ahmad Aljada   +7 more
doaj   +1 more source

Dataset on characterization of recombinant interleukin-23α, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining

Data in Brief, 2018
The data herein is related to the research article entitled “Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex” [1] where we demonstrated that the chicken interleukin (IL)-23α ...
Anh Duc Truong, Cong Thanh Hoang, Yeojin Hong, Janggeun Lee, Kyungbaek Lee, Hyun S. Lillehoj, Yeong Ho Hong   +6 more
doaj   +1 more source

The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes.

Haematologica, 2002
Interleukin-12 (IL-12) is a heterodimeric cytokine that induces interferon-g (IFN-g) production by natural killer and T-lymphocytes. IL-12 also activates human B-cells through the IL-12 receptor (IL-12R) complex. Here we review the expression and function of IL-12 and IL-12R in human B-cells and in their malignant counterparts.The information provided ...
Irma, Airoldi, Roberta, Guglielmino, Giuseppe, Carra, Anna, Corcione, Franca, Gerosa, Giuseppe, Taborelli, Giorgio, Trinchieri, Vito, Pistoia   +7 more
openaire   +2 more sources